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Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
(Royal Society of Chemistry, 2021)
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Article.
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Pharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. A controlled and on-demand release of PCs via ...
Experiencia para fomentar la motivación y el aprendizaje en los trabajos en grupo presentados en el aula. Cambiando el enfoque
(2021-10)
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Article.
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Tot i els innegables beneficis del treball en grup, freqüentment ens trobem amb problemes de falta de motivació per part de l'alumnat. En la present comunicació es mostra una experiència desenvolupada a fi de fomentar la ...
Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase
(2019-01-01)
Article.
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Article.
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Ambroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded ß-glucocerebrosidase (GCase) while displaying a safe toxicological profile. In this work, different ...
Nanotheranostic Interface Based on Antibiotic-Loaded Conducting Polymer Nanoparticles for Real-Time Monitoring of Bacterial Growth Inhibition
(2020-12-18)
Article.
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Article.
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Conducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping–dedoping characteristics, high ...
Proteolytic enzymes in detergents: evidence of their presence through activity measurements based on electrophoresis
(2011)
Article.
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Article.
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This laboratory exercise uses a problem-based approach to expose
students to some basic concepts relating to proteins and enzymes. One of the main
applications of enzymes at the industrial level is their use in the ...
Two high-mobility group box domains act together to underwind and kink DNA.
(2015-07-02)
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Article.
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High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ...
Antibacterial hydrogelsderived from poly(¿-glutamic acid) nanofibers
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-14)
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Article.
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Biocompatible hydrogels with antibacterial properties derived from ¿-polyglutamic acid (¿-PGA) were prepared from bulk and electrospun nanofibers. The antibacterial drugs loaded in these hydrogels were triclosan (TCS), ...
Paternal contribution to development: sperm genetic damage and repair in fish
(2017-04-01)
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Article.
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In this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization, showing the relationship between the integrity of the diverse elements and ...
Aplicación al aprendizaje de técnicas de purificación y análisis de proteínas
(2014)
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Article.
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A menudo el aprendizaje de técnicas experimentales en el laboratorio se ofrece en forma de prácticas independientes inconexas en las que el alumno aprende una o unas pocas de ellas en cada sesión. ...
Spermiogenesis and biflagellate spermatozoon of the teleost fish Lampanyctus crocodilus (Myctophiformes, Myctophidae): ultrastructure and characterisation of its sperm basic nuclear proteins
(2015-08-01)
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Article.
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We undertook an ultrastructural study of the spermiogenesis of the lanternfish Lampanyctus crocodilus (Myctophiformes, Myctophidae) with special emphasis on the condensation of chromatin and the biochemical characterisation ...