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Experiencia para fomentar la motivación y el aprendizaje en los trabajos en grupo presentados en el aula. Cambiando el enfoque
(2021-10)
Article
Open AccessTot i els innegables beneficis del treball en grup, freqüentment ens trobem amb problemes de falta de motivació per part de l'alumnat. En la present comunicació es mostra una experiència desenvolupada a fi de fomentar la ... -
The influence of Ni2+ and other ions on the trigonal structure of DNA
(Wiley, 2021-04-13)
Article
Open AccessWe present a new structure of a DNA dodecamer obtained in the presence of Ni2+ ions. The DNA forms Ni-guanine cross-links between neighboring molecules. Our results show that an adequate dosage of Ni2+ may help to form ... -
Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
(Royal Society of Chemistry, 2021)
Article
Open AccessPharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. A controlled and on-demand release of PCs via ... -
Nanotheranostic Interface Based on Antibiotic-Loaded Conducting Polymer Nanoparticles for Real-Time Monitoring of Bacterial Growth Inhibition
(2020-12-18)
Article
Open AccessConducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping–dedoping characteristics, high ... -
Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase
(2019-01-01)
Article
Open AccessAmbroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded ß-glucocerebrosidase (GCase) while displaying a safe toxicological profile. In this work, different ... -
Evolution of tandem repeat satellite sequences in two closely related caenorhabditis species: Diminution of satellites in hermaphrodites
(2017-12-01)
Article
Open AccessThe availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to ... -
Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair
(2017-07-19)
Article
Restricted access - publisher's policyA diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ... -
Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast
(2017-08-21)
Article
Open AccessTrypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ... -
Paternal contribution to development: sperm genetic damage and repair in fish
(2017-04-01)
Article
Open AccessIn this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization, showing the relationship between the integrity of the diverse elements and ... -
Crystalline structure and thermotropic behavior of alkyltrimethylphosphonium amphiphiles
(2017-02-14)
Article
Open AccessQuaternary organophosphonium salts bearing long alkyl chains are cationic surfactants of interest owing to their physical and biological properties. In the present work, the crystal structure and thermotropic behavior of ... -
Intercalative DNA binding of the marine anticancer drug variolin B
(Macmillan Publishers, 2017-01-04)
Article
Open AccessVariolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic ... -
Paternal contribution to development: Spermgenetic damage and repair in fish
(2016)
Article
Open AccessIn this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization , showing the relationship between the integrity of the diverse elements and ...
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