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Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase
(2019-01-01)
Article
Open AccessAmbroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded ß-glucocerebrosidase (GCase) while displaying a safe toxicological profile. In this work, different ... -
Evolution of tandem repeat satellite sequences in two closely related caenorhabditis species: Diminution of satellites in hermaphrodites
(2017-12-01)
Article
Open AccessThe availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to ... -
Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair
(2017-07-19)
Article
Restricted access - publisher's policyA diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ... -
Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast
(2017-08-21)
Article
Open AccessTrypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ... -
Paternal contribution to development: sperm genetic damage and repair in fish
(2017-04-01)
Article
Open AccessIn this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization, showing the relationship between the integrity of the diverse elements and ... -
Crystalline structure and thermotropic behavior of alkyltrimethylphosphonium amphiphiles
(2017-02-14)
Article
Open AccessQuaternary organophosphonium salts bearing long alkyl chains are cationic surfactants of interest owing to their physical and biological properties. In the present work, the crystal structure and thermotropic behavior of ... -
Intercalative DNA binding of the marine anticancer drug variolin B
(Macmillan Publishers, 2017-01-04)
Article
Open AccessVariolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic ... -
Paternal contribution to development: Spermgenetic damage and repair in fish
(2016)
Article
Open AccessIn this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization , showing the relationship between the integrity of the diverse elements and ... -
Spermiogenesis and biflagellate spermatozoon of the teleost fish Lampanyctus crocodilus (Myctophiformes, Myctophidae): ultrastructure and characterisation of its sperm basic nuclear proteins
(2015-08-01)
Article
Open AccessWe undertook an ultrastructural study of the spermiogenesis of the lanternfish Lampanyctus crocodilus (Myctophiformes, Myctophidae) with special emphasis on the condensation of chromatin and the biochemical characterisation ... -
High evolutionary turnover of satellite families in Caenorhabditis
(2015-10-05)
Article
Open AccessBackground: The high density of tandem repeat sequences (satellites) in nematode genomes and the availability of genome sequences from several species in the group offer a unique opportunity to better understand the ... -
Two high-mobility group box domains act together to underwind and kink DNA.
(2015-07-02)
Article
Open AccessHigh-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ... -
Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds
(2015-03-17)
Article
Open AccessThe traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...
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