MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
El nucli central d'aquest grup és l'estudi de macromolècules biològiques per mètodes de cristal·lografia. S'ha estudiat un gran nombre d'estructures d'oligonucleòtids sintètics que han donat una valuosa informació de noves formes del DNA (Hoogsteen, recombinants, superhèlixs, etc.).
S'estudia també l'estructura i la funció de diverses proteïnes i fàrmacs que interactuen amb el DNA. Les proteïnes i les seves variants es preparen directament dels teixits o per clonació i expressió en procariotes, utilitzant també tècniques de mutagènesi dirigida.
The main objective of the team is the study of biological macromolecules using crystallographic methods. Many synthetic oligonucleotide structures have been studied, which have provided information on new DNA forms (Hoogsteen, recombinants, superhelix, etc.).
The team also studies the structure and function of several proteins and drugs, as well as their interactions with DNA. The proteins and their variants are prepared directly from the tissue or by expression in procariotes. Site-directed mutagenesis is also used.
The main objective of the team is the study of biological macromolecules using crystallographic methods. Many synthetic oligonucleotide structures have been studied, which have provided information on new DNA forms (Hoogsteen, recombinants, superhelix, etc.).
The team also studies the structure and function of several proteins and drugs, as well as their interactions with DNA. The proteins and their variants are prepared directly from the tissue or by expression in procariotes. Site-directed mutagenesis is also used.
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Articles de revista [29]
Recent Submissions
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Antibacterial hydrogelsderived from poly(¿-glutamic acid) nanofibers
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-14)
Article
Open AccessBiocompatible hydrogels with antibacterial properties derived from ¿-polyglutamic acid (¿-PGA) were prepared from bulk and electrospun nanofibers. The antibacterial drugs loaded in these hydrogels were triclosan (TCS), ... -
Exams as an "in extremis" learning tool
(Adaya Press, 2021)
Conference report
Open AccessThe so-called testing effect has been known for a long time: we retain knowledge better if after initial learning we carry out an exam on this material than with its mere re-study or the elaboration of concept maps (Karpicke ... -
Experiencia para fomentar la motivación y el aprendizaje en los trabajos en grupo presentados en el aula. Cambiando el enfoque
(2021-10)
Article
Open AccessTot i els innegables beneficis del treball en grup, freqüentment ens trobem amb problemes de falta de motivació per part de l'alumnat. En la present comunicació es mostra una experiència desenvolupada a fi de fomentar la ... -
The influence of Ni2+ and other ions on the trigonal structure of DNA
(Wiley, 2021-04-13)
Article
Open AccessWe present a new structure of a DNA dodecamer obtained in the presence of Ni2+ ions. The DNA forms Ni-guanine cross-links between neighboring molecules. Our results show that an adequate dosage of Ni2+ may help to form ... -
Conducting polymer nanoparticles for voltage-controlled release of pharmacological chaperones
(Royal Society of Chemistry, 2021)
Article
Open AccessPharmacological chaperones (PCs) are low-molecular weight chemical molecules used in patients for the treatment of some rare diseases caused primarily by protein instability. A controlled and on-demand release of PCs via ... -
Nanotheranostic Interface Based on Antibiotic-Loaded Conducting Polymer Nanoparticles for Real-Time Monitoring of Bacterial Growth Inhibition
(2020-12-18)
Article
Open AccessConducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping–dedoping characteristics, high ... -
New drugs complexed with AT-rich DNA against neglected diseases
(2019)
Conference lecture
Restricted access - publisher's policy -
Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase
(2019-01-01)
Article
Open AccessAmbroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded ß-glucocerebrosidase (GCase) while displaying a safe toxicological profile. In this work, different ... -
Sustained release of a pharmacological chaperone that increases the activity of misfolded ß-Glucocerebrosidase
(2019)
Conference lecture
Open Access -
Evolution of tandem repeat satellite sequences in two closely related caenorhabditis species: Diminution of satellites in hermaphrodites
(2017-12-01)
Article
Open AccessThe availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to ... -
Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair
(2017-07-19)
Article
Restricted access - publisher's policyA diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ... -
Proteïnes espermàtiques bàsiques i patró de condensació dela cromatina de l'espermatozoide biflagel·lat dels peixos mictòfids
(Societat Catalana de Biologia (SCB), 2017)
Conference report
Restricted access - publisher's policyLes proteïnes espermàtiques bàsiques (PEB) associades al nucli de les esparmàtides madures i espermatozoides de Lampanyctus crocodilus presenten un patró complex on coexisteixen histones juntament amb dos grups de proteïnes ...
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