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dc.contributor.authorMaione, Silvana
dc.contributor.authorGil, Ana M.
dc.contributor.authorFabregat Jové, Georgina
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorTriguero Enguídanos, Jordi
dc.contributor.authorLaurent, A.
dc.contributor.authorJacquemin, Denis
dc.contributor.authorEstrany Coda, Francesc
dc.contributor.authorJimenez Sanz, Ana Isabel
dc.contributor.authorZanuy Gomara, David
dc.contributor.authorCativiela, Carlos
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2016-01-26T12:45:28Z
dc.date.available2017-01-03T01:30:41Z
dc.date.issued2015-01-01
dc.identifier.citationMaione, S., Gil, A., Fabregat, G., del Valle, LJ., Triguero, J., Laurent, A., Jacquemin, D., Estrany, F., Jimenez, A., Zanuy, D., Cativiela, C., Aleman, C. Electroactive polymer-peptide conjugates for adhesive biointerfaces. "Biomaterials science", 01 Gener 2015, vol. 3, núm. 10, p. 1395-1405.
dc.identifier.issn2047-4830
dc.identifier.urihttp://hdl.handle.net/2117/82053
dc.description.abstractElectroactive polymer-peptide conjugates have been synthesized by combining poly(3,4-ethylenedioxythiophene), a polythiophene derivative with outstanding properties, and an Arg-Gly-Asp (RGD)-based peptide in which Gly has been replaced by an exotic amino acid bearing a 3,4-ethylenedioxythiophene ring in the side chain. The incorporation of the peptide at the ends of preformed PEDOT chains has been corroborated by both FTIR and X-ray photoelectron spectroscopy. Although the morphology and topology are not influenced by the incorporation of the peptide at the ends of PEDOT chains, this process largely affects other surface properties. Thus, the wettability of the conjugates is considerably higher than that of PEDOT, independently of the synthetic strategy, whereas the surface roughness only increases when the conjugate is obtained using a competing strategy (i.e. growth of the polymer chains against termination by end capping). The electrochemical activity of the conjugates has been found to be higher than that of PEDOT, evidencing the success of the polymer-peptide links designed by chemical similarity. Density functional theory calculations have been used not only to ascertain the conformational preferences of the peptide but also to interpret the electronic transitions detected by UV-vis spectroscopy. Electroactive surfaces prepared using the conjugates displayed the higher bioactivities in terms of cell adhesion, with the relative viabilities being dependent on the roughness, wettability and electrochemical activity of the conjugate. In addition to the influence of the peptide fragment in the initial cell attachment and subsequent cell spreading and survival, the results indicate that PEDOT promotes the exchange of ions at the conjugate-cell interface.
dc.format.extent11 p.
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshPolymers
dc.subject.lcshPeptides
dc.subject.otherCell-adhesion
dc.subject.otherchemical similarity
dc.subject.otherconducting polymer
dc.subject.otherblock-copolymers
dc.subject.otherrgd
dc.subject.otherintegrins
dc.subject.otherpoly(3
dc.subject.other4-ethylenedioxythiophene)
dc.subject.otherproliferation
dc.subject.othernanofibers
dc.subject.otherxps
dc.titleElectroactive polymer-peptide conjugates for adhesive biointerfaces
dc.typeArticle
dc.subject.lemacPolímers conductors
dc.subject.lemacPèptids
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM - Innovació, Modelització i Enginyeria en (BIO) Materials
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.1039/c5bm00160a
dc.rights.accessOpen Access
drac.iddocument16980243
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/278845/EU/Modelling of Architectures Ruled by Coupled or Heightened Excited States/MARCHES
upcommons.citation.authorMaione, S.; Gil, A.; Fabregat, G.; del Valle, LJ.; Triguero, J.; Laurent, A.; Jacquemin, D.; Estrany, F.; Jimenez, A.; Zanuy, D.; Cativiela, C.; Aleman, C.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameBiomaterials science
upcommons.citation.volume3
upcommons.citation.number10
upcommons.citation.startingPage1395
upcommons.citation.endingPage1405


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