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dc.contributor.authorPérez Amodio, Soledad Graciela
dc.contributor.authorRubio, Nuria
dc.contributor.authorVila, Olaia
dc.contributor.authorNavarro Requena, Claudia
dc.contributor.authorCastaño, Óscar
dc.contributor.authorSanchez Ferrero, Aitor
dc.contributor.authorMartí Muñoz, Joan
dc.contributor.authorAlsina Gibert, Merce
dc.contributor.authorBlanco Fernández, Jerónimo
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2021-03-09T13:09:25Z
dc.date.issued2020-08-07
dc.identifier.citationPerez, S. [et al.]. Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice. "Advances in Wound Care", 7 Agost 2020, p. 1-17.
dc.identifier.issn2162-1918
dc.identifier.urihttp://hdl.handle.net/2117/341303
dc.description.abstractObjective: Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, resulting in nonhealing chronic wounds. Chronic wounds are a socioeconomic burden, one of the most prominent clinical manifestations of diabetes, however, they lack satisfactory treatment options. The objective of this study was to develop polymeric composites that deliver ions having wound healing properties and evaluate its performance using a pressure ulcer model in diabetic mice. Approach: To develop a polymeric composite wound dressing containing ion-releasing nanoparticles for chronic wound healing. This composite was chemically and physically characterized and evaluated using a pressure ulcer wound model in diabetic (db/db) mice to explore their potential as novel wound dressing. Results: This dressing exhibits a controlled ion release and a good in vitro bioactivity. The polymeric composite dressing treatment stimulates angiogenesis, collagen synthesis, granulation tissue formation, and accelerates wound closure of ischemic wounds created in diabetic mice. In addition, the performance of the newly designed composite is remarkably better than a commercially available dressing frequently used for the treatment of low-exuding chronic wounds. Innovation: The developed nanoplatforms are cell- and growth factor free and control the host microenvironment resulting in enhanced wound healing. These nanoplatforms are available by cost-effective synthesis with a defined composition, offering an additional advantage in potential clinical application. Conclusion: Based on the obtained results, these polymeric composites offer an optimum approach for chronic wound healing without adding cells or external biological factors.
dc.format.extent17 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshBioengineering
dc.subject.otherAngiogenesis
dc.subject.otherBioactive dressings
dc.subject.otherChronic wounds
dc.subject.otherDiabetes
dc.titlePolymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice
dc.typeArticle
dc.subject.lemacBioenginyeria
dc.subject.lemacDiabetis -- Tractament
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.1089/wound.2020.1206
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://pubmed.ncbi.nlm.nih.gov/32602814/
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac29925685
dc.description.versionPostprint (author's final draft)
dc.date.lift2021-08-07
local.citation.authorPerez, S.; Rubio, N.; Vila, O.; Navarro, C.; Castaño, Ó.; Sanchez, A.; Martí-Muñoz, J.; Alsina, M.; Blanco Fernández, Jerónimo; Engel, E.
local.citation.publicationNameAdvances in Wound Care
local.citation.startingPage1
local.citation.endingPage17


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain