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Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice

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10.1089/wound.2020.1206
 
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Pérez Amodio, Soledad GracielaMés informacióMés informació
Rubio, Nuria
Vila, Olaia
Navarro Requena, Claudia
Castaño, Óscar
Sanchez Ferrero, Aitor
Martí Muñoz, JoanMés informació
Alsina Gibert, Merce
Blanco Fernández, Jerónimo
Engel López, ElisabethMés informacióMés informacióMés informació
Document typeArticle
Defense date2020-08-07
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Objective: Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, resulting in nonhealing chronic wounds. Chronic wounds are a socioeconomic burden, one of the most prominent clinical manifestations of diabetes, however, they lack satisfactory treatment options. The objective of this study was to develop polymeric composites that deliver ions having wound healing properties and evaluate its performance using a pressure ulcer model in diabetic mice. Approach: To develop a polymeric composite wound dressing containing ion-releasing nanoparticles for chronic wound healing. This composite was chemically and physically characterized and evaluated using a pressure ulcer wound model in diabetic (db/db) mice to explore their potential as novel wound dressing. Results: This dressing exhibits a controlled ion release and a good in vitro bioactivity. The polymeric composite dressing treatment stimulates angiogenesis, collagen synthesis, granulation tissue formation, and accelerates wound closure of ischemic wounds created in diabetic mice. In addition, the performance of the newly designed composite is remarkably better than a commercially available dressing frequently used for the treatment of low-exuding chronic wounds. Innovation: The developed nanoplatforms are cell- and growth factor free and control the host microenvironment resulting in enhanced wound healing. These nanoplatforms are available by cost-effective synthesis with a defined composition, offering an additional advantage in potential clinical application. Conclusion: Based on the obtained results, these polymeric composites offer an optimum approach for chronic wound healing without adding cells or external biological factors.
CitationPerez, S. [et al.]. Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice. "Advances in Wound Care", 7 Agost 2020, p. 1-17. 
URIhttp://hdl.handle.net/2117/341303
DOI10.1089/wound.2020.1206
ISSN2162-1918
Publisher versionhttps://pubmed.ncbi.nlm.nih.gov/32602814/
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  • Departament de Ciència i Enginyeria de Materials - Articles de revista [656]
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