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dc.contributor.authorAinsbury, Elizabeth A.
dc.contributor.authorGinjaume Egido, Mercè
dc.contributor.authorChumak, Vadim
dc.contributor.authorStruelens, L.
dc.contributor.otherUniversitat Politècnica de Catalunya. Institut de Tècniques Energètiques
dc.date.accessioned2021-02-16T12:10:37Z
dc.date.available2021-02-16T12:10:37Z
dc.date.issued2021-01-01
dc.identifier.citationAinsbury, E. [et al.]. Radiation-induced lens opacities: Epidemiological, clinical and experimental evidence, methodological issues, research gaps and strategy. "Environment international", 1 Gener 2021, vol. 146, núm. 106213, p. 106213:1-106213:14.
dc.identifier.issn0160-4120
dc.identifier.urihttp://hdl.handle.net/2117/339770
dc.description.abstractIn 2011, the International Commission on Radiological Protection (ICRP) recommended reducing the occupational equivalent dose limit for the lens of the eye from 150 mSv/year to 20 mSv/year, averaged over five years, with no single year exceeding 50 mSv. With this recommendation, several important assumptions were made, such as lack of dose rate effect, classification of cataracts as a tissue reaction with a dose threshold at 0.5 Gy, and progression of minor opacities into vision-impairing cataracts. However, although new dose thresholds and occupational dose limits have been set for radiation-induced cataract, ICRP clearly states that the recommendations are chiefly based on epidemiological evidence because there are a very small number of studies that provide explicit biological and mechanistic evidence at doses under 2 Gy. Since the release of the 2011 ICRP statement, the Multidisciplinary European Low Dose Initiative (MELODI) supported in April 2019 a scientific workshop that aimed to review epidemiological, clinical and biological evidence for radiation-induced cataracts. The purpose of this article is to present and discuss recent related epidemiological and clinical studies, ophthalmic examination techniques, biological and mechanistic knowledge, and to identify research gaps, towards the implementation of a research strategy for future studies on radiation-induced lens opacities. The authors recommend particularly to study the effect of ionizing radiation on the lens in the context of the wider, systemic effects, including in the retina, brain and other organs, and as such cataract is recommended to be studied as part of larger scale programs focused on multiple radiation health effects.
dc.language.isoeng
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights©2021. Elsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subjectÀrees temàtiques de la UPC::Física::Electromagnetisme
dc.subjectÀrees temàtiques de la UPC::Ciències de la visió::Instruments òptics i optomètrics
dc.subject.lcshLonizing radiation
dc.subject.lcshRadiological protection
dc.subject.otherLens of the eyeIonizing radiation
dc.subject.otherOpacities
dc.subject.otherMechanisms
dc.subject.otherThreshold
dc.subject.otherRadiation protection
dc.titleRadiation-induced lens opacities: Epidemiological, clinical and experimental evidence, methodological issues, research gaps and strategy
dc.typeArticle
dc.subject.lemacRadiació ionitzant
dc.subject.lemacProtecció radiològica
dc.contributor.groupUniversitat Politècnica de Catalunya. DRM - Dosimetria i Radiofísica Mèdica
dc.identifier.doi10.1016/j.envint.2020.106213
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0160412020321681
dc.rights.accessOpen Access
local.identifier.drac30537612
dc.description.versionPostprint (published version)
local.citation.authorAinsbury, E.; Ginjaume, M.; Chumak, V.; Struelens, L.
local.citation.publicationNameEnvironment international
local.citation.volume146
local.citation.number106213
local.citation.startingPage106213:1
local.citation.endingPage106213:14


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