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Calcium phosphate cements loaded with basic fibroblast growth factor: Delivery and in vitro cell response
dc.contributor.author | Perez, Roman |
dc.contributor.author | Kim, Tae-Hyun |
dc.contributor.author | Kim, Meeju |
dc.contributor.author | Jang, Jun-Hyeog |
dc.contributor.author | Ginebra Molins, Maria Pau |
dc.contributor.author | Kim, Hae-Won |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2013-07-02T10:57:12Z |
dc.date.created | 2013-04 |
dc.date.issued | 2013-04 |
dc.identifier.citation | Perez, R.A. [et al.]. Calcium phosphate cements loaded with basic fibroblast growth factor: Delivery and in vitro cell response. "Journal of biomedical materials research. Part A", Abril 2013, vol. 101A, núm. 4, p. 923-931. |
dc.identifier.issn | 1549-3296 |
dc.identifier.uri | http://hdl.handle.net/2117/19763 |
dc.description.abstract | biological responses, especially in terms of cell proliferation. Here, we used basic fibroblast growth factor (bFGF) in an -tricalcium phosphate cement with different initial powder sizes (coarse vs. fine; designated as CPC-C and CPC-F, respectively) and investigated the behavior of bFGF loading and release, as well as the effects on osteoblast responses. bFGF was loaded at 10 g/ml or 25 g/ml onto the set form of two types of CPCs, aiming to allow penetration into the pore structure and adsorption onto the cement crystallites. The CPC formulated with fine powder (CPC-F) had higher specific surface area and smaller-sized pores and retained slightly higher amounts of bFGF within the structure. The bFGF release study performed for 3 weeks showed a sustained-release profile; after an initial rapid release over approximately... |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.subject.lcsh | Biomaterials |
dc.subject.other | calcium phosphate cements |
dc.subject.other | powder size |
dc.subject.other | growth factor delivery |
dc.subject.other | cell proliferation |
dc.subject.other | bone regeneration |
dc.title | Calcium phosphate cements loaded with basic fibroblast growth factor: Delivery and in vitro cell response |
dc.type | Article |
dc.subject.lemac | Biomaterials |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1002/jbm.a.34390 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 12435003 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
dc.contributor.covenantee | Centro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina |
dc.contributor.covenantee | Tan'guk Taehakkyo |
local.citation.author | Perez, R.A.; Kim, T.H; Kim, M.; Jang, JH; Ginebra, M.P.; Kim, HW |
local.citation.publicationName | Journal of biomedical materials research. Part A |
local.citation.volume | 101A |
local.citation.number | 4 |
local.citation.startingPage | 923 |
local.citation.endingPage | 931 |
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