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dc.contributor.authorHoyo Pérez, Javier
dc.contributor.authorIvanova, Kristina Dimitrova
dc.contributor.authorTorrent Burgués, Juan
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2020-05-12T09:53:28Z
dc.date.available2020-05-12T09:53:28Z
dc.date.issued2020-05-08
dc.identifier.citationHoyo, J. [et al.]. Interaction of silver-lignin nanoparticles with mammalian mimetic membranes. "Frontiers in Bioengineering and Biotechnology", 8 Maig 2020, vol. 8, p. 439-1-439-8.
dc.identifier.issn2296-4185
dc.identifier.urihttp://hdl.handle.net/2117/187235
dc.description.abstractSilver nanoparticles (AgNPs) have broad spectrum antibacterial activity, but their toxicity to human cells has raised concerns related to their use as disinfectants or coatings of medically relevant surfaces. To address this issue, NPs comprising intrinsically bactericidal and biocompatible biopolymer and Ag with high antibacterial efficacy against common pathogens and compatibility to human cells have been engineered. However, the reason for their lower toxicity compared to AgNPs has not yet been elucidated. This work studies the in vitro interaction of AgLNPs with model mammalian membranes through two approaches: (i) Langmuir films and (ii) supported planar bilayers studied by quartz crystal microbalance and atomic force spectroscopy. These approaches elucidate the interactions of AgLNPs with the model membranes indicating a prominent effect of the bioresourced lignin to facilitate the binding of AgLNPs to the mammalian membrane, without penetrating through it. This study opens a new avenue for engineering of hybrid antimicrobial biopolymer – Ag or other metal NPs with improved bactericidal effect whereas maintaining good biocompatibility
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshNanoparticles
dc.subject.lcshPolymers -- Deterioration
dc.subject.lcshBiopolymers
dc.subject.otherModel mammalian membrane
dc.subject.otherSilver-lignin nanoparticles
dc.subject.otherAtomic force microscopy
dc.subject.otherQuartz crystal microbalance
dc.subject.otherLangmuir film
dc.titleInteraction of silver-lignin nanoparticles with mammalian mimetic membranes
dc.typeArticle
dc.subject.lemacNanopartícules
dc.subject.lemacPolímers -- Deterioració
dc.subject.lemacBiopolímers
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.3389/fbioe.2020.00439
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fbioe.2020.00439/full
dc.rights.accessOpen Access
local.identifier.drac28108032
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/720851/EU/Pre-commercial lines for production of surface nanostructured antimicrobial and anti-biofilm textiles, medical devices and water treatment membranes/PROTECT
local.citation.authorHoyo, J.; Ivanova, K.; Torrent-Burgués, J.; Tzanov, T.
local.citation.publicationNameFrontiers in Bioengineering and Biotechnology
local.citation.volume8
local.citation.startingPage439-1
local.citation.endingPage439-8


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Attribution 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution 3.0 Spain