El grup de recerca treballa en el camp de l'estructura-funció de proteïnes d'interès biomèdic i biotecnològic. Es porta a terme el disseny i l?obtenció de proteïnes recombinants mitjançant tècniques d'enginyeria genètica. Aquestes proteïnes són purificades i caracteritzades per tècniques bioquímiques i espectroscòpiques. També es treballa en la modificació d'enzims per a aplicacions en processos biotecnològics d'interès industrial.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

Recent Submissions

  • Discovery of hit compounds targeting the P4 allosteric site of K-RAS, identified through ensemble-based virtual screening 

    Gómez Gutiérrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (American Chemical Society, 2023-10-12)
    Article
    Open Access
    Mutants of Ras are oncogenic drivers of a large number of human tumors. Despite being recognized as an attractive target for the treatment of cancer, the high affinity for its substrate tagged the protein as undruggable ...
  • Engineering a point-of-care paper-microfluidic electrochemical device applied to the multiplexed quantitative detection of biomarkers in sputum 

    Gutierrez Capitan, Manuel; Sanchís Villariz, Ana; Carvalho, Estela; Baldi Coll, Antonio; Vilaplana Holgado, Lluïsa; Cardoso, Vanessa; Calleja Navalpotro, Álvaro; Wei, Mingxing; de la Rica, Roberto; Hoyo Pérez, Javier; Bassegoda Puigdomenech, Arnau; Tzanov, Tzanko; Marco Colas, María Pilar; Lanceros Méndez, Senentxu; Fernandez Sanchez, Cesar (American Chemical Society (ACS), 2023-07-19)
    Article
    Open Access
    Health initiatives worldwide demand affordable point- of-care devices to aid in the reduction of morbidity and mortality rates of high-incidence infectious and noncommunicable diseases. However, the production of robust ...
  • Continuous sonochemical nanotransformation of lignin - process design and control 

    Pérez Rafael, Silvia; Ferreres Cabanes, Guillem; Kessler, Rudolf; Kessler, Waltraud; Blair González, Jeniffer; Rathee, Garima; Morena, Angela Gala; Tzanov, Tzanko (2023-06)
    Article
    Open Access
    As the most abundant renewable aromatic polymer on the planet, lignin is gaining growing interest in replacing petroleum-based chemicals and products. However, only <5 % of industrial lignin waste is revalorized in its ...
  • Effect of trace metal Ions on the conformational stability of the visual photoreceptor rhodopsin 

    Wang, Feifei; Fernández González, Pol; Ramon Portés, Eva; Gómez Gutiérrez, Patricia; Morillo Cazorla, Margarita; Garriga Solé, Pere (Multidisciplinary Digital Publishing Institute (MDPI), 2023-07-01)
    Article
    Open Access
    Trace metals are essential elements that play key roles in a number of biochemical processes governing human visual physiology in health and disease. Several trace metals, such as zinc, have been shown to play important ...
  • A step forward toward selective activation/inhibition of bak, a pro-apoptotic member of the Bcl-2 protein family: discovery of new prospective allosteric sites using molecular dynamics 

    Vila i Julià, Guillem; Pérez González, Juan Jesús; Rubio Martinez, Jaime (American Chemical Society, 2023-01-01)
    Article
    Restricted access - publisher's policy
    Bak is a pro-apoptotic protein and a member of the Bcl-2 family that plays a key role in apoptosis, a programmed cell death mechanism of multicellular organisms. Its activation under death stimuli triggers the permeabilization ...
  • Influence of enzymatically hydrophobized hemp protein on morphology and mechanical properties of bio-based polyurethane and epoxy foams 

    Ferreres Cabanes, Guillem; Pérez Rafael, Silvia; Morena Gatius, Ángela Gala; Tzanov, Tzanko; Gryshchuk, Liudmyla (Multidisciplinary Digital Publishing Institute (MDPI), 2023-08-31)
    Article
    Open Access
    Biomass fillers offer the possibility to modify the mechanical properties of foams, increasing their cost-effectiveness and reducing their carbon footprint. In this study, bio-based PU (soft, open cells for the automotive ...
  • Lignin–cobalt nano-enabled poly(pseudo)rotaxane supramolecular hydrogel for treating chronic wounds 

    Crivello, Giulia; Orlandini, Giuliana; Morena, Angela Gala; Torchio, Alessandro; Mattu, Clara; Boffito, Monica; Tzanov, Tzanko; Ciardelli, Gianluca (Multidisciplinary Digital Publishing Institute (MDPI), 2023-06-13)
    Article
    Open Access
    Chronic wounds (CWs) are a growing issue for the health care system. Their treatment requires a synergic approach to reduce both inflammation and the bacterial burden. In this work, a promising system for treating CWs was ...
  • Tear film constituents and medicines for eyes investigated as Langmuir films 

    Torrent Burgués, Juan (Springer Nature, 2023-05-06)
    Article
    Open Access
    The tear flm has an important role on the quality of the vision process and is of importance in the felds of ophthalmology and optometry. The lipid layer, the outermost part of the tear flm, can be investigated with the ...
  • Multimodal silver-chitosan-acylase nanoparticles inhibit bacterial growth and biofilm formation by gram-negative pseudomonas aeruginosa bacterium 

    Ferreres Cabanes, Guillem; Ivanova, Kristina Dimitrova; Torrent Burgués, Juan; Tzanov, Tzanko (2023-05)
    Article
    Open Access
    Pseudomonas aeruginosa bacteria originate severe infections in hospitalized patients and those with chronic debilitating diseases leading to increased morbidity and mortality, longer hospitalization and huge financial ...
  • Effects of solvents on the conformational profile of Balaram's peptide: a computational study 

    Gómez Gutiérrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (Royal Society of Chemistry (RSC), 2022-10-28)
    Article
    Open Access
    The present work reports the results of a computational study aimed at characterizing the conformational profile of Balaram's peptide (Ace-Leu-Val-Val-Aib-Gly-Leu-Val-Val-NHMe) in different solvents, including chloroform, ...
  • Nanomaterials and coatings for managing antibiotic-resistant biofilms 

    Ferreres Cabanes, Guillem; Ivanova, Kristina Dimitrova; Ivanov, Ivan; Tzanov, Tzanko (2023-02-02)
    Article
    Open Access
    Biofilms are a global health concern responsible for 65 to 80% of the total number of acute and persistent nosocomial infections, which lead to prolonged hospitalization and a huge economic burden to the healthcare systems. ...
  • Rigid composite bio-based polyurethane foams: from synthesis to LCA analysis 

    Recupido, Federica; Lama, Giuseppe C.; Ammendola, Mario; De Lucca Bossa, Ferdinando; Minigher, Andrea; Campaner, Pietro; Morena Gatius, Ángela Gala; Tzanov, Tzanko; Ornelas, Mariana; Barros, Ana; Gomes, Filipa; Bouça, Veronica; Malagueiro, Regina; Sanchez, Monica; Martinez, Eva; Sorrentino, Luigi; Boggioni, Laura; Perucca, Massimo; Anegalla, Sridhar; Marzella, Roberta; Moimare, Pierluigi; Verdolotti, Letizia (Elsevier, 2023-01)
    Article
    Restricted access - publisher's policy
    Our current industrial ammonia cycle is far from being sustainable – while intense energy is required to produce ammonia – almost half of it ends up in wastewater treatment plants (WWTPs) where is finally transformed and ...

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