El grup de recerca treballa en el camp de l'estructura-funció de proteïnes d'interès biomèdic i biotecnològic. Es porta a terme el disseny i l?obtenció de proteïnes recombinants mitjançant tècniques d'enginyeria genètica. Aquestes proteïnes són purificades i caracteritzades per tècniques bioquímiques i espectroscòpiques. També es treballa en la modificació d'enzims per a aplicacions en processos biotecnològics d'interès industrial.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

Recent Submissions

  • Hybrid tellurium-lignin nanoparticles with enhanced antibacterial properties 

    Morena Gatius, Ángela Gala; Bassegoda Puigdomenech, Arnau; Hoyo Pérez, Javier; Tzanov, Tzanko (2021-04-07)
    Article
    Restricted access - publisher's policy
    The surge of antibiotic-resistant bacteria is leading to the loss of antibiotic treatment effectiveness, resulting in prolonged infections and even death. Against this healthcare threat, antimicrobial nanoparticles that ...
  • New insights into the stereochemical requirements of the bombesin BB1 receptor antagonists binding 

    Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-08-17)
    Article
    Open Access
    Members of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. ...
  • Discovery of a bradykinin b2 partial agonist profile of raloxifene in a drug repurposing campaign 

    Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-12-29)
    Article
    Open Access
    Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing. ...
  • Anti-inflammatory effect of amygdalin analogs following topical administration on the TPA-induced irritant contact dermatitis model in mice 

    Pérez González, Juan Jesús (2021-01-26)
    Article
    Open Access
    Amygdalin is a cyanogenic glycoside found in seeds of apricots, peaches, almonds, and other rosaceous stone fruits. A few years ago, amygdalin was identified as a peptidomimetic of peptide T, a compound that had been ...
  • Interactions of cryoprotective agents with phospholipid membranes - A Langmuir monolayer study 

    Raju, Rekha; Torrent Burgués, Juan; Bryant, Gary (2020-09)
    Article
    Open Access
    The influence of four common cryoprotectants (dimethyl sulfoxide, glycerol, ethylene glycol and dimethylformamide) on monolayers of four common phospholipids (DPPC, DOPC, POPC and POPE) have been studied using Langmuir ...
  • Antimicrobial lightweight materials and components 

    Morena Gatius, Ángela Gala; Ferreres Cabanes, Guillem; Ivanova, Kristina Dimitrova; Pérez Rafael, Silvia; Tzanov, Tzanko (Elsevier, 2020-12-02)
    Part of book or chapter of book
    Restricted access - publisher's policy
    Lightweight materials and components have gained remarkable scientific and technological importance in the recent times as the main drivers of innovation. They are finding widespread use across all industry sectors to ...
  • Molecular features of non-selective small molecule antagonists of the Bradykinin receptors 

    Rasaeifar, Bahareh; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2020-09-21)
    Article
    Open Access
    Angiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of ...
  • Structural study of a retro-enantiomer peptide with possible application in the pre-exposure prophylaxis of HIV infection 

    Gómara Elena, María José; Pérez, Yolanda; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (Nature, 2020-09-02)
    Article
    Open Access
    Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater ...
  • Sonochemical coating of Prussian Blue for the production of smart bacterial-sensing hospital textiles 

    Ferrer Vilanova, Amparo; Alonso, Yasmine; Dietvorst, Jiri; Pérez-Montero, Marta; Rodríguez-Rodríguez, Rosalía; Ivanova, Kristina Dimitrova; Tzanov, Tzanko; Vigués, Núria; Mas, Jordi; Guirado, Gonzalo; Muñoz-Berbel, Xavier (2020-08-27)
    Article
    Restricted access - publisher's policy
    In healthcare facilities, environmental microbes are responsible for numerous infections leading to patient’s health complications and even death. The detection of the pathogens present on contaminated surfaces is crucial, ...
  • Antibody-enabled antimicrobial nanocapsules for selective elimination of Staphylococcus aureus 

    Ivanova, Kristina Dimitrova; Asenova Ivanova, Aleksandra; Ramon Portés, Eva; Hoyo Pérez, Javier; Sanchez-Gomez, Susana; Tzanov, Tzanko (2020-07-16)
    Article
    Restricted access - publisher's policy
    Targeted bactericide nanosystems hold significant promise to improve the efficacy of existing antimicrobials for treatment of severe bacterial infections, minimizing the side effects and lowering the risk of antibiotic ...
  • A fungal ascorbate oxidase with unexpected laccase activity 

    Braunschmid, Verena; Fuerst, Sarah; Perz, veronika; Zitzenbacher, Sabine; Hoyo Pérez, Javier; Fernandez Sanchez, Cesar; Tzanov, Tzanko; Steinkellner, Georg; Gruber, Karl; Nyanhongo, Gibson S.; Ribitsch, Doris; Guebitz, Georg (2020-08-11)
    Article
    Open Access
    Ascorbate oxidases are an enzyme group that has not been explored to a large extent. So far, mainly ascorbate oxidases from plants and only a few from fungi have been described. Although ascorbate oxidases belong to the ...
  • Assessment of the conformational profile of bombesin by computational methods 

    Valverde Salamanca, Abel; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-07-20)
    Article
    Restricted access - publisher's policy
    In the present work, the results of a computational study aimed at assessing the conformational profile of bombesin are reported. The conformational space of the peptide was sampled by means of a 4 µs accelerated molecular ...

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