El grup de recerca treballa en el camp de l'estructura-funció de proteïnes d'interès biomèdic i biotecnològic. Es porta a terme el disseny i l?obtenció de proteïnes recombinants mitjançant tècniques d'enginyeria genètica. Aquestes proteïnes són purificades i caracteritzades per tècniques bioquímiques i espectroscòpiques. També es treballa en la modificació d'enzims per a aplicacions en processos biotecnològics d'interès industrial.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

Recent Submissions

  • Cobalt-phenolic nanoparticles-driven self-assembly of hyaluronic acid hydrogels providing a multifactorial approach for chronic wound management 

    Ferreres Cabanes, Guillem; Pérez Rafael, Silvia; Palacios Bonilla, Òscar; Todorova, Katerina; Hinojosa-Caballero, Dolores; Torrent Burgués, Juan; Tzanov, Tzanko (2024-06-13)
    Article
    Open Access
    Chronic wounds are persistent non-healing lesions whose complex management is due to the interplay of multiple factors promoting chronicity, such as oxidative stress, overexpressed enzyme activities impeding the tissue ...
  • Dual electro-/pH-responsive nanoparticle/hydrogel system for controlled delivery of anticancer peptide 

    Resina, Maria Leonor Matos; Esteves, Teresa; Pérez Rafael, Silvia; Hernández García, José Ignacio; Castelo Ferreira, Frederico; Tzanov, Tzanko; Bonardd, Sebastián; Díaz Díaz, David; Pérez Madrigal, Maria del Mar; Alemán Llansó, Carlos (Elsevier, 2024-06)
    Article
    Restricted access - publisher's policy
    An electro-chemo-responsive carrier has been engineered for the controlled release of a highly hydrophilic anticancer peptide, CR(NMe)EKA (Cys-Arg- N-methyl-Glu-Lys-Ala). Remotely controlled on demand release of CR(NMe)EKA, ...
  • Mussel-inspired sonochemical nanocomposite coating on catheters for prevention of urinary infections 

    Puertas Segura, Antonio Jesús; Ivanova, Kristina Dimitrova; Ivanova, Anzhelika; Ivanov, Ivan; Todorova, Katerina; Dimitrov, Petar; Ciardelli, Gianluca; Tzanov, Tzanko (2024-06-25)
    Article
    Open Access
    Catheter-associated urinary tract infections are the most common hospital-acquired infections and cause patient discomfort, increased morbidity, and prolonged stays, altogether posing a huge burden on healthcare services. ...
  • The discovery of inhibitors of the SARS-CoV-2 S protein through computational drug repurposing 

    Avilés Alía, Ana Isabel; Zulaica, Joao; Pérez González, Juan Jesús; Rubio Martínez, Jaime; Geller, Ron; Granadino Roldán, José Manuel (Elsevier, 2024-03)
    Article
    Open Access
    SARS-CoV-2 must bind its principal receptor, ACE2, on the target cell to initiate infection. This interaction is largely driven by the receptor binding domain (RBD) of the viral Spike (S) protein. Accordingly, antiviral ...
  • Ionic liquids as biocompatible antibacterial agents: a case study on structure-related bioactivity on Escherichia coli 

    Fernandes, Margarida M.; Carvalho, Estela; Correia, Daniela M.; Esperança, José M.S.S.; Padrão, Jorge; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Tzanov, Tzanko; Lanceros Méndez, Senentxu (American Chemical Society, 2022-10-19)
    Article
    Open Access
    The potential of ionic liquids (ILs) to be used as antimicrobial agents for biomedical applications has been hindered by the fact that most of them are cytotoxic toward mammalian cells. Understanding the mechanism of ...
  • Protein-rich rafts in hybrid polymer/lipid giant unilamellar vesicles 

    Otrin, Nika; Bednarz, Claudia; Otrin, Lado; Ivanov, Ivan; Träger, Toni K.; Hamdi, Farzad; Kastritis, Panagiotis L.; Sundmacher, Kai (2024-01-08)
    Article
    Open Access
    Considerable attention has been dedicated to lipid rafts due to their importance in numerous cell functions such as membrane trafficking, polarization, and signaling. Next to studies in living cells, artificial micrometer-sized ...
  • Assessment of the bound conformation of bombesin to the BB1 and BB2 receptors 

    Vila i Julià, Guillem; Rubio Martinez, Jaime; Pérez González, Juan Jesús (Elsevier, 2024-01-01)
    Article
    Restricted access - publisher's policy
    Bombesin is an endogenous peptide involved in a wide spectrum of physiological activities ranging from satiety, control of circadian rhythm and thermoregulation in the central nervous system, to stimulation of gastrointestinal ...
  • Estudi fisicoquímic de llàgrimes artificials i solucions de lents de contacte 

    Torrent Burgués, Juan (2023-12-01)
    Research report
    Open Access
  • Discovery of hit compounds targeting the P4 allosteric site of K-RAS, identified through ensemble-based virtual screening 

    Gómez Gutiérrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (American Chemical Society, 2023-10-12)
    Article
    Open Access
    Mutants of Ras are oncogenic drivers of a large number of human tumors. Despite being recognized as an attractive target for the treatment of cancer, the high affinity for its substrate tagged the protein as undruggable ...
  • Engineering a point-of-care paper-microfluidic electrochemical device applied to the multiplexed quantitative detection of biomarkers in sputum 

    Gutierrez Capitan, Manuel; Sanchís Villariz, Ana; Carvalho, Estela; Baldi Coll, Antonio; Vilaplana Holgado, Lluïsa; Cardoso, Vanessa; Calleja Navalpotro, Álvaro; Wei, Mingxing; de la Rica, Roberto; Hoyo Pérez, Javier; Bassegoda Puigdomenech, Arnau; Tzanov, Tzanko; Marco Colas, María Pilar; Lanceros Méndez, Senentxu; Fernandez Sanchez, Cesar (American Chemical Society (ACS), 2023-07-19)
    Article
    Open Access
    Health initiatives worldwide demand affordable point- of-care devices to aid in the reduction of morbidity and mortality rates of high-incidence infectious and noncommunicable diseases. However, the production of robust ...
  • Continuous sonochemical nanotransformation of lignin - process design and control 

    Pérez Rafael, Silvia; Ferreres Cabanes, Guillem; Kessler, Rudolf; Kessler, Waltraud; Blair González, Jeniffer; Rathee, Garima; Morena, Angela Gala; Tzanov, Tzanko (2023-06)
    Article
    Open Access
    As the most abundant renewable aromatic polymer on the planet, lignin is gaining growing interest in replacing petroleum-based chemicals and products. However, only <5 % of industrial lignin waste is revalorized in its ...
  • Effect of trace metal Ions on the conformational stability of the visual photoreceptor rhodopsin 

    Wang, Feifei; Fernández González, Pol; Ramon Portés, Eva; Gómez Gutiérrez, Patricia; Morillo Cazorla, Margarita; Garriga Solé, Pere (Multidisciplinary Digital Publishing Institute (MDPI), 2023-07-01)
    Article
    Open Access
    Trace metals are essential elements that play key roles in a number of biochemical processes governing human visual physiology in health and disease. Several trace metals, such as zinc, have been shown to play important ...

View more