El grup de recerca treballa en el camp de l'estructura-funció de proteïnes d'interès biomèdic i biotecnològic. Es porta a terme el disseny i l?obtenció de proteïnes recombinants mitjançant tècniques d'enginyeria genètica. Aquestes proteïnes són purificades i caracteritzades per tècniques bioquímiques i espectroscòpiques. També es treballa en la modificació d'enzims per a aplicacions en processos biotecnològics d'interès industrial.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

Recent Submissions

  • Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies 

    Ruffo, Mariarosa; Parisi, Ortensia Ilaria; Dattilo, Marco; Patitucci, Francesco; Malivindi, Rocco; Pezzi, Vincenzo; Tzanov, Tzanko; Puoci, Francesco (Springer Nature, 2022-03-31)
    Article
    Open Access
    In diabetic patients, the presence of neuropathy, peripheral vascular diseases and ischemia, leads to the formation of foot ulcerations with a higher risk of infection because the normal response to bacterial infection is ...
  • Electrical monitoring of infection biomarkers in chronic wounds using nanochannels 

    Iglesias-Mayor, Alba; Amor-Gutiérez, Olaya; Toyos-Rodríguez, Celia; Bassegoda Puigdomenech, Arnau; Tzanov, Tzanko; Escosura-Muñiz, Alfredo de la (2022-08-01)
    Article
    Open Access
    Chronic wounds represent an important healthcare challenge in developed countries, being wound infection a serious complication with significant impact on patients’ life conditions. However, there is a lack of methods ...
  • Discovery of novel 2,3,5-trisubstituted pyridine analogs as potent inhibitors of IL-1ß via modulation of the p38 MAPK signaling pathway 

    Carrasco, Esther; Gómez Gutierrez, Patricia; Campos Muelas, Pedro Manuel; Vega, Miguel; Messeguer, Angel; Pérez González, Juan Jesús (2021-11-05)
    Article
    Open Access
    Interleukin-1ß is a central mediator of innate immune responses and inflammation. It plays a key role in a wide variety of pathologies, ranging from autoinflammatory diseases to metabolic syndrome and malignant tumors. It ...
  • Effect of sodium valproate on the conformational stability of the visual G Protein-coupled receptor rhodopsin 

    Razzaghi, Neda; Fernández González, Pol; Mas Sánchez, Aina; Vila i Julià, Guillem; Pérez González, Juan Jesús; Garriga Solé, Pere (2021-05-19)
    Article
    Open Access
    Rhodopsin is the G protein-coupled receptor of rod photoreceptor cells that mediates vertebrate vision at low light intensities. Mutations in rhodopsin cause inherited retinal degenerative diseases such as retinitis ...
  • Effects of cryoprotectants on phospholipid monolayers - concentration and species dependence 

    Raju, Rekha; Torrent Burgués, Juan; Bryant, Gary (2022-03)
    Article
    Open Access
    The effects of four cryoprotectants (dimethylformamide (DMF), ethylene glycol (EG), glycerol and dimethyl sulfoxide (DMSO)) on monolayers of four phospholipids were investigated at high cryoprotectant concentration (10% ...
  • Fragment dissolved molecular dynamics: a systematic and efficient method to locate binding sites 

    Privat, Cristian; Granadino, Jose Manuel; Bonet Ruiz, Jordi; Tomás Belenguer, María Santos; Pérez González, Juan Jesús; Rubio Martínez, Jaime (Royal Society of Chemistry (RSC), 2021)
    Article
    Open Access
    Diverse computational methods to support Fragment-based drug discovery (FBDD) are available in the literature. Despite their demonstrated efficacy to support FBDD campaigns, they exhibit some drawbacks such as protein ...
  • Discovery of diverse natural products as inhibitors of SARS-CoV-2 Mpro protease through virtual screening 

    Rubio Martínez, Jaime; Jiménez Alesanco, Ana; Ceballos Laita, Laura; Ortega Alarcón, David; Vega, Sonia; Calvo, Cristina; Benítez García, Cristina; Abian, Olga; Velázquez Campoy, Adrián; Thomson, Timothy M.; Granadino Roldán, José Manuel; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2021-11-22)
    Article
    Restricted access - publisher's policy
    SARS-CoV-2 is a type of coronavirus responsible for the international outbreak of respiratory illness termed COVID-19 that forced the World Health Organization to declare a pandemic infectious disease situation of international ...
  • Characterization of modified solid electrodes with organized thin films of a tetra-substituted zinc phthalocyanine 

    Guaus Guerrero, Ester; Torrent Burgués, Juan (2022-04-01)
    Article
    Open Access
    Organized thin films of a zinc phthalocyanine have been deposited on solid electrodes using several techniques, such as drop casting, immersion and Langmuir-Blodgett (LB), at several conditions, and their electrochemical ...
  • Lysozyme influence on monolayers of individual and mixed lipids 

    Torrent Burgués, Juan (Multidisciplinary Digital Publishing Institute (MDPI), 2022-03)
    Article
    Open Access
    Fatty acids, cholesterol, and phospholipids are amphiphilic compounds of biological interest, which form ordered monolayers mimicking biomembranes, and can be studied with the Langmuir technique using surface pressure-area ...
  • Electrochemical quantification of biomarker myeloperoxidase 

    Hoyo Pérez, Javier; Bassegoda Puigdomenech, Arnau; Tzanov, Tzanko (2022-02-22)
    Article
    Restricted access - publisher's policy
    Point of care testing (PoCT) devices permit precise and rapid detection of disease-related biomarkers contributing to an early disease diagnosis and administration of an appropriate treatment. The enzyme myeloperoxidase ...
  • Strategies for silencing bacterial 

    Ivanova, Kristina Dimitrova; Tzanov, Tzanko; Fernandes Macedo, Margarida Maria (Springer India, 2015-10-03)
    Part of book or chapter of book
    Restricted access - publisher's policy
    Recent advances in microbiology have revealed that bacteria are able to communicate and cooperate in a wide range of multicellular behaviors such as dispersal, foraging and biofilm formation, in a process called quorum ...
  • Hyaluronic acid derivative molecular weight-dependent synthesis and antimicrobial effect of hybrid silver nanoparticles 

    Ferreres Cabanes, Guillem; Pérez Rafael, Silvia; Torrent Burgués, Juan; Tzanov, Tzanko (2021-12-14)
    Article
    Open Access
    Silver nanoparticles (Ag NPs) appeared as promising antimicrobial candidates to face the development of antibiotic resistance. Although reported as toxic towards mammalian cells, their combination with biomolecules have ...

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