El grup de recerca treballa en el camp de l'estructura-funció de proteïnes d'interès biomèdic i biotecnològic. Es porta a terme el disseny i l?obtenció de proteïnes recombinants mitjançant tècniques d'enginyeria genètica. Aquestes proteïnes són purificades i caracteritzades per tècniques bioquímiques i espectroscòpiques. També es treballa en la modificació d'enzims per a aplicacions en processos biotecnològics d'interès industrial.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

The research group works on the structure and function of proteins of biomedical and biotechnological relevance. Recombinant proteins are designed and obtained by means of genetic engineering techniques. These proteins are purified and characterised using biochemical and spectroscopic methods. Enzyme engineering and modification are also studied, for their application to biotechnological processes in industry.

Recent Submissions

  • Skin tastes bitter molecules through the bitter taste receptors 

    Roca, Angela; Perez Aso, Miguel; Tena Campos, Mercè; Garriga Solé, Pere; Bosch, Jordi; Martinez Teipel, Blanca (2018)
    Conference lecture
    Restricted access - publisher's policy
  • Effect of lysozyme subphase and insertion on several lipid films 

    Torrent Burgués, Juan; Raju, Rekha (2019-06)
    Article
    Open Access
    The influence of proteins on lipid monolayers is a subject of biological interest. In this work the influence of lysozyme on lipid films of stearic acid, oleic acid, cholesterol, DPPC and POPC has been studied. The Langmuir ...
  • Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management 

    Ruseva, Konstans; Ivanova, Kristina Dimitrova; Todorova, Katerina; Gabrashanska, Margarita; Hinojosa-Caballero, Dolores; Tzanov, Tzanko; Vassileva, Elena (Elsevier, 2019-05-14)
    Article
    Restricted access - publisher's policy
    Polyzwitterions (PZI) recently emerged as biomaterials with excellent bio- and haemo-compatibility, demonstrating lower protein adsorption on their surfaces even compared to the golden standard in the field – poly(ethylene ...
  • Action potential propagation: ion current or intramembrane electric field? 

    Martí Cabarrocas, Albert; Pérez González, Juan Jesús; Madrenas Boadas, Jordi (2018-01-22)
    Article
    Open Access
    The established action potential propagation mechanisms do not satisfactorily explain propagation on myelinated axons given the current knowledge of biological channels and membranes. The flow across ion channels presents ...
  • Effect of set up protocols on the accuracy of alchemical free energy calculation over a set of ACK1 inhibitors 

    Granadino, Jose Manuel; Mey, Antonia S. J. S.; Pérez González, Juan Jesús; Bosisio, Stefano; Rubio Martínez, Jaime; Michel, Julien (Public Library of Science (PLOS), 2019-03-01)
    Article
    Open Access
    Hit-to-lead virtual screening frequently relies on a cascade of computational methods that starts with rapid calculations applied to a large number of compounds and ends with more expensive computations restricted to a ...
  • Electrical evaluation of bacterial virulence factors using nanopores 

    Escosura Muñiz, Alfredo de la; Ivanova, Kristina Dimitrova; Tzanov, Tzanko (2019-03-19)
    Article
    Restricted access - publisher's policy
    In this work, we propose a novel methodology for electrical monitoring using nanoporous alumina membranes of virulence factors secreted by bacterial pathogens. Bacterial hyaluronidase (HYAL), which is produced by a number ...
  • Biomedical textiles 

    Stefanov, Ivaylo; Bassegoda Puigdomenech, Arnau; Tzanov, Tzanko (Elsevier, 2019-07-01)
    Part of book or chapter of book
    Restricted access - publisher's policy
    The use of textiles in medicine dates back to ancient times. In modern medicine, textile fibers can be found in a wide variety of biomedical devices from simple non-woven bandages for wounds to complex hollow fiber membranes ...
  • Ligand binding mechanisms in human cone visual pigments 

    Srinivasan, Sundaramoorthy; Guixà González, Ramon; Cordomí, Arnau; Garriga Solé, Pere (2019-07)
    Article
    Restricted access - publisher's policy
    Vertebrate vision starts with light absorption by visual pigments in rod and cone photoreceptor cells of the retina. Rhodopsin, in rod cells, responds to dim light, whereas three types of cone opsins (red, green, and blue) ...
  • Multifunctional ZnO NPs-chitosan-gallic acid hybrid nanocoating to overcome contact lenses associated conditions and discomfort 

    Hoyo Pérez, Javier; Ivanova, Kristina Dimitrova; Guaus Guerrero, Ester; Tzanov, Tzanko (2019-02-13)
    Article
    Restricted access - publisher's policy
    Contact lenses (CL) provide visual correction but their use may also induce several adverse effects causative of discomfort and conditions that lead to stop or discontinue their use. Discomfort is mainly caused by insufficient ...
  • Molecular features characterizing non-peptide selectivity to the human B1 and B2 bradykinin receptors 

    Rasaeifar, B.; Lupala, C.S.; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2019-01-01)
    Article
    Restricted access - publisher's policy
    Bradykinin is produced in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases. Actions of this peptide are mediated through two different G-protein coupled receptors, named B1 and B2 ...
  • Physical states and thermodynamic properties of model Gram-negative bacterial inner membranes 

    Hoyo Pérez, Javier; Torrent Burgués, Juan; Tzanov, Tzanko (2018-12-06)
    Article
    Restricted access - publisher's policy
    Novel antimicrobial agents are focused to interact with the bacterial membrane whose lipid composition (number and position of unsaturations and lipid headgroup) is adapted according to environmental signals. The anticipation ...
  • Metal-enzyme nanoaggregates eradicate both gram-positive and gram-negative bacteria and their biofilms 

    Ferreres Cabanes, Guillem; Bassegoda Puigdomenech, Arnau; Hoyo Pérez, Javier; Torrent Burgués, Juan; Tzanov, Tzanko (2018-11-13)
    Article
    Restricted access - publisher's policy
    To palliate the appearance of antimicrobial resistance (AMR), the use of bactericidal agents acting differently than conventional antibiotics and the elimination of bacterial biofilm, are the two most promising strategies. ...

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