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  Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death 

  Fernandez, Ana M.; Hervas, Ruben; Dominguez Fraile, Manuel; Garrido Victoria, Navarro; Gómez Gutiérrez, Patricia; Vega, Miguel; Vitorica, Javier; Pérez González, Juan Jesús; Torres Aleman, Ignacio (2016-01-01)
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  Acceso abierto

  Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ...
• Human blue cone opsin regeneration involves secondary retinal binding with analog specificity 

  Srinivasan, Sundaramoorthy; Fernández Sampedro, Miguel Ángel; Morillo Cazorla, Margarita; Ramon Portés, Eva; Jiménez Rosés, Mireia; Cordomi, Arnau; Garriga Solé, Pere (2018-03-27)
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  Acceso restringido por política de la editorial

  Human color vision is mediated by the red, green, and blue cone visual pigments. Cone opsins are G-protein-coupled receptors consisting of an opsin apoprotein covalently linked to the 11-cis-retinal chromophore. All visual ...
• Durable antimicrobial cotton textiles coated sonochemically with ZnO nanoparticles embedded in an in-situ enzymatically generated bioadhesive 

  Salat, Marc; Petkova, Petya; Hoyo Pérez, Javier; Perelshtein, Ilana; Gedanken, Aharon; Tzanov, Tzanko (2018-02-14)
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  Acceso restringido por política de la editorial

  An important preventive measure for providing a bacteria-free environment for the patients is the introduction of highly efficient and durable antibacterial textiles in hospitals. This work describes a single step ...
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  Tuning ubiquinone position in biomimetic monolayer membranes 

  Hoyo Pérez, Javier; Guaus Guerrero, Ester; Torrent Burgués, Juan (2017-06-19)
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  Acceso abierto

  Artificial lipid bilayers have been extensively studied as models that mimic natural membranes (biomimetic membranes). Several attempts of biomimetic membranes inserting ubiquinone (UQ) have been performed to enlighten ...
• Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials 

  Bassegoda Puigdomenech, Arnau; Ivanova, Kristina Dimitrova; Ramon, Eva; Tzanov, Tzanko (2018-02-01)
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  Acceso restringido por política de la editorial

  Drug resistance occurrence is a global healthcare concern responsible for the increased morbidity and mortality in hospitals, time of hospitalisation and huge financial loss. The failure of the most antibiotics to kill ...
• Layer-by-layer decorated nanoparticles with tunable antibacterial and antibiofilm properties against both gram-positive and gram-negative bacteria 

  Asenova Ivanova, Aleksandra; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Sanchez-Gomez, Susana; Heinze, Thomas; Tzanov, Tzanko (2018-01-09)
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  Acceso restringido por política de la editorial

  acteria-mediated diseases are a global healthcare concern due to the development and spread of antibiotic resistant strains. Cationic compounds are considered membrane active biocidal agents having a great potential to ...
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  Identification of potential small molecule binding pockets in p38a MAP kinase 

  Gómez Gutierrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (2017-10-23)
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  Acceso abierto

  Given the essential role played by protein kinases in regulating cellular pathways, their dysregulation can result in the onset and/or progression of various human diseases. Structural analysis of diverse protein kinases ...
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  Effect of the solvent on the conformational behavior of the alanine dipeptide deduced from MD simulations 

  Rubio Martínez, Jaime; Tomás Belenguer, María Santos; Pérez González, Juan Jesús (2017-11-01)
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  Acceso abierto

  In general, peptides do not exhibit a well-defined conformational profile in solution. However, despite the experimental blurred picture associated with their structure, compelling spectroscopic evidence shows that peptides ...
• Hydrogel dressings for advanced wound management 

  Francesko, Antonio; Petkova, Petya; Tzanov, Tzanko (2017-09-20)
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  Acceso restringido por política de la editorial

  Composed in a large extent of water and due to their non-adhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the ...
• Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling 

  Lupala, Cecylia Severin; Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2017-08-13)
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  Acceso restringido por política de la editorial

  Despite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ...
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  Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa 

  Herrera Hernández, María Guadalupe; Ramon Portés, Eva; Lupala, Cecylia Severin; Tena Campos, Mercè; Pérez González, Juan Jesús; Garriga Solé, Pere (Macmillan Publishers, 2017-12-01)
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  Acceso abierto

  Dietary flavonoids exhibit many biologically-relevant functions and can potentially have beneficial effects in the treatment of pathological conditions. In spite of its well known antioxidant properties, scarce structural ...
• Structural study of a new HIV-1 entry inhibitor and interaction with the HIV-1 fusion peptide in dodecylphosphocholine micelles 

  Pérez González, Juan Jesús; Pérez, Yolanda; Gómara, Maria José; Yuste, Eloísa; Gómez Gutierrez, Patricia; Haro, Isabel (2017-07-03)
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  Acceso restringido por política de la editorial

  Previous studies support the hypothesis that the envelope GB virus C (GBV-C) E1 protein interferes the HIV-1 entry and that a peptide, derived from the region 139-156 of this protein, has been defined as a novel HIV-1 entry ...

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