Recent Submissions

  • Molecular features of non-selective small molecule antagonists of the Bradykinin receptors 

    Rasaeifar, Bahareh; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2020-09-21)
    Article
    Open Access
    Angiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of ...
  • Structural study of a retro-enantiomer peptide with possible application in the pre-exposure prophylaxis of HIV infection 

    Gómara Elena, María José; Pérez, Yolanda; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (Nature, 2020-09-02)
    Article
    Open Access
    Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater ...
  • Sonochemical coating of Prussian Blue for the production of smart bacterial-sensing hospital textiles 

    Ferrer Vilanova, Amparo; Alonso, Yasmine; Dietvorst, Jiri; Pérez-Montero, Marta; Rodríguez-Rodríguez, Rosalía; Ivanova, Kristina Dimitrova; Tzanov, Tzanko; Vigués, Núria; Mas, Jordi; Guirado, Gonzalo; Muñoz-Berbel, Xavier (2020-08-27)
    Article
    Restricted access - publisher's policy
    In healthcare facilities, environmental microbes are responsible for numerous infections leading to patient’s health complications and even death. The detection of the pathogens present on contaminated surfaces is crucial, ...
  • Antibody-enabled antimicrobial nanocapsules for selective elimination of Staphylococcus aureus 

    Ivanova, Kristina Dimitrova; Asenova Ivanova, Aleksandra; Ramon Portés, Eva; Hoyo Pérez, Javier; Sanchez-Gomez, Susana; Tzanov, Tzanko (2020-07-16)
    Article
    Restricted access - publisher's policy
    Targeted bactericide nanosystems hold significant promise to improve the efficacy of existing antimicrobials for treatment of severe bacterial infections, minimizing the side effects and lowering the risk of antibiotic ...
  • A fungal ascorbate oxidase with unexpected laccase activity 

    Braunschmid, Verena; Fuerst, Sarah; Perz, veronika; Zitzenbacher, Sabine; Hoyo Pérez, Javier; Fernandez Sanchez, Cesar; Tzanov, Tzanko; Steinkellner, Georg; Gruber, Karl; Nyanhongo, Gibson S.; Ribitsch, Doris; Guebitz, Georg (2020-08-11)
    Article
    Open Access
    Ascorbate oxidases are an enzyme group that has not been explored to a large extent. So far, mainly ascorbate oxidases from plants and only a few from fungi have been described. Although ascorbate oxidases belong to the ...
  • Assessment of the conformational profile of bombesin by computational methods 

    Valverde Salamanca, Abel; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-07-20)
    Article
    Restricted access - publisher's policy
    In the present work, the results of a computational study aimed at assessing the conformational profile of bombesin are reported. The conformational space of the peptide was sampled by means of a 4 µs accelerated molecular ...
  • Molecular determinants for the activation/inhibition of bak protein by BH3 peptides 

    Vila Julià, Guillem; Granadino, Jose Manuel; Pérez González, Juan Jesús; Rubio Martínez, Jaime (2020-03-23)
    Article
    Open Access
    Apoptosis is a key cell death pathway in mammalian cells. Understanding this process and its regulation has been a subject of study in the last three decades. Members of the Bcl-2 family of proteins are involved in the ...
  • Layer-by-Layer coating of aminocellulose and quorum quenching acylase on silver nanoparticles synergistically eradicate bacteria and their biofilms 

    Asenova Ivanova, Aleksandra; Ivanova, Kristina Dimitrova; Tied, Antje; Heinze, Thomas; Tzanov, Tzanko (2020-04-24)
    Article
    Open Access
    The emergence of antibiotic-resistant bacteria and the failure of the existing antibacterial therapeutics call for development of novel treatment strategies. Furthermore, the formation of bacterial biofilms restricts drug ...
  • A potential lignocellulosic biomass based on banana waste for critical rare earths recovery from aqueous solutions 

    Lapo Calderón, Byron Gonzalo; Bou Serra, Jordi; Hoyo Pérez, Javier; Tzanov, Tzanko; Carrillo, Manuel; Peña, Karina; Sastre Requena, Ana María (2020-04-29)
    Article
    Restricted access - publisher's policy
    Rare earth elements (REE) present multiple applications in technological devices but also drawbacks (scarcity and water contaminant). The current study aims to valorise the banana wastes - banana rachis (BR), banana ...
  • Interaction of silver-lignin nanoparticles with mammalian mimetic membranes 

    Hoyo Pérez, Javier; Ivanova, Kristina Dimitrova; Torrent Burgués, Juan; Tzanov, Tzanko (Frontiers Media SA, 2020-05-08)
    Article
    Open Access
    Silver nanoparticles (AgNPs) have broad spectrum antibacterial activity, but their toxicity to human cells has raised concerns related to their use as disinfectants or coatings of medically relevant surfaces. To address ...
  • Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings 

    Ruseva, Konstans; Ivanova, Kristina Dimitrova; Todorova, Katerina; Vladov, Ivelin; Nanev, Vesselin; Tzanov, Tzanko; Hinojosa-Caballero, Dolores; Argirova, Maya; Vassileva, Elena (Elsevier, 2020-04-12)
    Article
    Restricted access - publisher's policy
    The current study demonstrates the benefits of poly(carboxybetaine methacrylate) hydrogels in chronic wound healing. These hydrogels demonstrate high absorbing capacity upon swelling in salt solutions thus revealing great ...
  • Lipid-lipid interactions of Escherichia coli mimetic inner membrane at human physiological temperature 

    Hoyo Pérez, Javier; Torrent Burgués, Juan; Tzanov, Tzanko (2020-03-26)
    Article
    Open Access
    The current strategies to eradicate bacteria require that the antimicrobial agent either penetrate or disrupt the bacterial membrane. In Escherichia coli (E.coli) as a model of Gram-negative strains, the antimicrobials ...

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