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A step forward toward selective activation/inhibition of bak, a pro-apoptotic member of the Bcl-2 protein family: discovery of new prospective allosteric sites using molecular dynamics
(American Chemical Society, 2023-01-01)
Article
Restricted access - publisher's policyBak is a pro-apoptotic protein and a member of the Bcl-2 family that plays a key role in apoptosis, a programmed cell death mechanism of multicellular organisms. Its activation under death stimuli triggers the permeabilization ... -
Influence of enzymatically hydrophobized hemp protein on morphology and mechanical properties of bio-based polyurethane and epoxy foams
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-08-31)
Article
Open AccessBiomass fillers offer the possibility to modify the mechanical properties of foams, increasing their cost-effectiveness and reducing their carbon footprint. In this study, bio-based PU (soft, open cells for the automotive ... -
Lignin–cobalt nano-enabled poly(pseudo)rotaxane supramolecular hydrogel for treating chronic wounds
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-06-13)
Article
Open AccessChronic wounds (CWs) are a growing issue for the health care system. Their treatment requires a synergic approach to reduce both inflammation and the bacterial burden. In this work, a promising system for treating CWs was ... -
Tear film constituents and medicines for eyes investigated as Langmuir films
(Springer Nature, 2023-05-06)
Article
Open AccessThe tear flm has an important role on the quality of the vision process and is of importance in the felds of ophthalmology and optometry. The lipid layer, the outermost part of the tear flm, can be investigated with the ... -
Multimodal silver-chitosan-acylase nanoparticles inhibit bacterial growth and biofilm formation by gram-negative pseudomonas aeruginosa bacterium
(2023-05)
Article
Open AccessPseudomonas aeruginosa bacteria originate severe infections in hospitalized patients and those with chronic debilitating diseases leading to increased morbidity and mortality, longer hospitalization and huge financial ... -
Effects of solvents on the conformational profile of Balaram's peptide: a computational study
(Royal Society of Chemistry (RSC), 2022-10-28)
Article
Restricted access - publisher's policyThe present work reports the results of a computational study aimed at characterizing the conformational profile of Balaram's peptide (Ace-Leu-Val-Val-Aib-Gly-Leu-Val-Val-NHMe) in different solvents, including chloroform, ... -
Nanomaterials and coatings for managing antibiotic-resistant biofilms
(2023-02-02)
Article
Open AccessBiofilms are a global health concern responsible for 65 to 80% of the total number of acute and persistent nosocomial infections, which lead to prolonged hospitalization and a huge economic burden to the healthcare systems. ... -
Rigid composite bio-based polyurethane foams: from synthesis to LCA analysis
(Elsevier, 2023-01)
Article
Restricted access - publisher's policyOur current industrial ammonia cycle is far from being sustainable – while intense energy is required to produce ammonia – almost half of it ends up in wastewater treatment plants (WWTPs) where is finally transformed and ... -
Bio-based nano-enabled cosmetic formulations for the treatment of cutibacterium acnes-associated skin infections
(2023-02-09)
Article
Open AccessAcne is a common chronic skin condition with serious physical and psychosocial consequences. In some cases, the appearance of pimples, whiteheads, or blackheads on the face, neck, and back may lead to scarring, disfiguring, ... -
Antibacterial lignin-based nanoparticles and their use in composite materials
(Royal Society of Chemistry (RSC), 2022-10-11)
Article
Open AccessLignin, one of the most abundant biopolymers on earth, has been traditionally considered a low-value by-product of the pulp and paper industries. This renewable raw material, besides being a source of valuable molecules ... -
Antibacterial properties and mechanisms of action of sonoenzymatically synthesized lignin-based nanoparticles
(2022-08-12)
Article
Open AccessIn recent years, lignin has drawn increasing attention for different applications due to its intrinsic antibacterial and antioxidant properties, coupled with biodegradability and biocompatibility. However, chemical ... -
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations
(Springer Nature, 2022-01-01)
Article
Open AccessMutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations, Y102H and I307N, obtained in chemically mutagenized mice, are currently ...
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