Enviaments recents

  • The Langmuir technique applied to the study of natural tears 

    Guaus Guerrero, Ester; Torrent Burgués, Juan (Springer, 2018-06-01)
    Article
    Accés restringit per política de l'editorial
    As a new proposal, natural tears collected from the Schirmer strips were studied using surface pressure-area, p-A, isotherms obtained with the Langmuir technique. Parameters such as limit surface pressure, plimit, elastic ...
  • Designing Peptidomimetics 

    Pérez González, Juan Jesús (2018-07-02)
    Article
    Accés restringit per política de l'editorial
    The concept of a peptidomimetic was coined about forty years ago. Since then, an enormous effort and interest has been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report ...
  • Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death 

    Fernandez, Ana M.; Hervas, Ruben; Dominguez Fraile, Manuel; Garrido Victoria, Navarro; Gómez Gutiérrez, Patricia; Vega, Miguel; Vitorica, Javier; Pérez González, Juan Jesús; Torres Aleman, Ignacio (2016-01-01)
    Article
    Accés obert
    Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ...
  • Human blue cone opsin regeneration involves secondary retinal binding with analog specificity 

    Srinivasan, Sundaramoorthy; Fernández Sampedro, Miguel Ángel; Morillo Cazorla, Margarita; Ramon Portés, Eva; Jiménez Rosés, Mireia; Cordomi, Arnau; Garriga Solé, Pere (2018-03-27)
    Article
    Accés restringit per política de l'editorial
    Human color vision is mediated by the red, green, and blue cone visual pigments. Cone opsins are G-protein-coupled receptors consisting of an opsin apoprotein covalently linked to the 11-cis-retinal chromophore. All visual ...
  • Durable antimicrobial cotton textiles coated sonochemically with ZnO nanoparticles embedded in an in-situ enzymatically generated bioadhesive 

    Salat, Marc; Petkova, Petya; Hoyo Pérez, Javier; Perelshtein, Ilana; Gedanken, Aharon; Tzanov, Tzanko (2018-02-14)
    Article
    Accés restringit per política de l'editorial
    An important preventive measure for providing a bacteria-free environment for the patients is the introduction of highly efficient and durable antibacterial textiles in hospitals. This work describes a single step ...
  • Tuning ubiquinone position in biomimetic monolayer membranes 

    Hoyo Pérez, Javier; Guaus Guerrero, Ester; Torrent Burgués, Juan (2017-06-19)
    Article
    Accés obert
    Artificial lipid bilayers have been extensively studied as models that mimic natural membranes (biomimetic membranes). Several attempts of biomimetic membranes inserting ubiquinone (UQ) have been performed to enlighten ...
  • Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials 

    Bassegoda Puigdomenech, Arnau; Ivanova, Kristina Dimitrova; Ramon, Eva; Tzanov, Tzanko (2018-02-01)
    Article
    Accés restringit per política de l'editorial
    Drug resistance occurrence is a global healthcare concern responsible for the increased morbidity and mortality in hospitals, time of hospitalisation and huge financial loss. The failure of the most antibiotics to kill ...
  • Layer-by-layer decorated nanoparticles with tunable antibacterial and antibiofilm properties against both gram-positive and gram-negative bacteria 

    Asenova Ivanova, Aleksandra; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Sanchez-Gomez, Susana; Heinze, Thomas; Tzanov, Tzanko (2018-01-09)
    Article
    Accés restringit per política de l'editorial
    acteria-mediated diseases are a global healthcare concern due to the development and spread of antibiotic resistant strains. Cationic compounds are considered membrane active biocidal agents having a great potential to ...
  • Identification of potential small molecule binding pockets in p38a MAP kinase 

    Gómez Gutierrez, Patricia; Rubio Martínez, Jaime; Pérez González, Juan Jesús (2017-10-23)
    Article
    Accés obert
    Given the essential role played by protein kinases in regulating cellular pathways, their dysregulation can result in the onset and/or progression of various human diseases. Structural analysis of diverse protein kinases ...
  • Effect of the solvent on the conformational behavior of the alanine dipeptide deduced from MD simulations 

    Rubio Martínez, Jaime; Tomás Belenguer, María Santos; Pérez González, Juan Jesús (2017-11-01)
    Article
    Accés obert
    In general, peptides do not exhibit a well-defined conformational profile in solution. However, despite the experimental blurred picture associated with their structure, compelling spectroscopic evidence shows that peptides ...
  • Hydrogel dressings for advanced wound management 

    Francesko, Antonio; Petkova, Petya; Tzanov, Tzanko (2017-09-20)
    Article
    Accés obert
    Composed in a large extent of water and due to their non-adhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the ...
  • Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling 

    Lupala, Cecylia Severin; Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2017-08-13)
    Article
    Accés obert
    Despite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ...

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