Characterization of 3D Printed Metal-PLA Composite Scaffolds for Biomedical Applications
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hdl:2117/374689
Tipus de documentArticle
Data publicació2022-07-05
EditorMultidisciplinary Digital Publishing Institute (MDPI)
Condicions d'accésAccés obert
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Reconeixement 4.0 Internacional
Abstract
Three-dimensional printing is revolutionizing the development of scaffolds due to their rapid-prototyping characteristics. One of the most used techniques is fused filament fabrication (FFF), which is fast and compatible with a wide range of polymers, such as PolyLactic Acid (PLA). Mechanical properties of the 3D printed polymeric scaffolds are often weak for certain applications. A potential solution is the development of composite materials. In the present work, metal-PLA composites have been tested as a material for 3D printing scaffolds. Three different materials were tested: copper-filled PLA, bronze-filled PLA, and steel-filled PLA. Disk-shaped samples were printed with linear infill patterns and line spacing of 0.6, 0.7, and 0.8 mm, respectively. The porosity of the samples was measured from cross-sectional images. Biocompatibility was assessed by culturing Human Bone Marrow-Derived Mesenchymal Stromal on the surface of the printed scaffolds. The results showed that, for identical line spacing value, the highest porosity corresponded to bronzefilled material and the lowest one to steel-filled material. Steel-filled PLA polymers showed good cytocompatibility without the need to coat the material with biomolecules. Moreover, human bone marrow-derived mesenchymal stromal cells differentiated towards osteoblasts when cultured on top of the developed scaffolds. Therefore, it can be concluded that steel-filled PLA bioprinted parts are valid scaffolds for bone tissue engineering
CitacióBuj-Corral, I. [et al.]. Characterization of 3D Printed Metal-PLA Composite Scaffolds for Biomedical Applications. "Polymers", 5 Juliol 2022, vol. 14, núm. 13, p. 2754:1-2754:12.
ISSN2073-4360
Versió de l'editorhttps://www.mdpi.com/2073-4360/14/13/2754
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polymers-14-02754-v2.pdf | 4,292Mb | Visualitza/Obre |