Potential periodontal regeneration by application of monoclonal antibodies against integrin-subunits a6 and b1
Cita com:
hdl:2099/5596
Tipus de documentArticle
Data publicació2001-12
EditorSociedad Ibérica de Biomecánica y Biomateriales
Condicions d'accésAccés obert
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continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
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Reconeixement-NoComercial-SenseObraDerivada 2.5 Espanya
Abstract
Successful guided tissue regeneration (GTR) should result in a functional attachment apparatus
of the periodontium. The crucial points in the healing process are potential microbiological
colonization of mechanical barrier membranes, lacking contact to the connective tissue and apical
growth of the gingival epithelium. The membranes‘ success might be improved by equipping them
with antibiotics, specific inhibitors for the epithelial growth and growth factors for periodontal
ligament cells (PLC) or progenitor cells. Monoclonal antibodies (mAb) directed to integrin subunits
a6 and b1 were tested for their specificity to epithelial growth. In vitro assays were performed as
direct and indirect contact by seeding the human HaCaT-cell-line and gingival fibroblasts.
CitacióGeorg Graber, Hans. [et al]. Potential periodontal regeneration by application of monoclonal antibodies against integrin-subunits a6 and b1. Biomecánica, 2001, vol. XI, núm. 1, p. 49-54.
ISSN1885-9518
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