Potential periodontal regeneration by application of monoclonal antibodies against integrin-subunits a6 and b1

Cita com:
hdl:2099/5596
Document typeArticle
Defense date2001-12
PublisherSociedad Ibérica de Biomecánica y Biomateriales
Rights accessOpen Access
This work is protected by the corresponding intellectual and industrial property rights.
Except where otherwise noted, its contents are licensed under a Creative Commons license
:
Attribution-NonCommercial-NoDerivs 2.5 Spain
Abstract
Successful guided tissue regeneration (GTR) should result in a functional attachment apparatus
of the periodontium. The crucial points in the healing process are potential microbiological
colonization of mechanical barrier membranes, lacking contact to the connective tissue and apical
growth of the gingival epithelium. The membranes‘ success might be improved by equipping them
with antibiotics, specific inhibitors for the epithelial growth and growth factors for periodontal
ligament cells (PLC) or progenitor cells. Monoclonal antibodies (mAb) directed to integrin subunits
a6 and b1 were tested for their specificity to epithelial growth. In vitro assays were performed as
direct and indirect contact by seeding the human HaCaT-cell-line and gingival fibroblasts.
CitationGeorg Graber, Hans. [et al]. Potential periodontal regeneration by application of monoclonal antibodies against integrin-subunits a6 and b1. Biomecánica, 2001, vol. XI, núm. 1, p. 49-54.
ISSN1885-9518
Files | Description | Size | Format | View |
---|---|---|---|---|
09 - Potential ... n by application of mo.pdf | 36,52Kb | View/Open |