Exploració per autor "Jaber, Qais Z."
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Benzylic Dehydroxylation of Echinocandin antifungal drugs restores efficacy against resistance conferred by mutated Glucan Synthase
Logviniuk, Dana; Jaber, Qais Z.; Dobrovetsky, Roman; Kozer, Noga; Ksiezopolska, Ewa; Gabaldón, Toni; Carmeli, Shmuel; Fridman, Micha (American Chemical Society (ACS), 2022-03)
Article
Accés obertEach year, infections caused by fungal pathogens claim the lives of about 1.6 million people and affect the health of over a billion people worldwide. Among the most recently developed antifungal drugs are the echinocandins, ... -
Elevated vacuolar uptake of fluorescently labeled antifungal drug caspofungin predicts echinocandin resistance in pathogenic yeast
Jaber, Qais Z.; Bibi, Maayan; Ksiezopolska, Ewa; Gabaldon, Toni; Berman, Judith; Fridman, Micha (American Chemical Society, 2020)
Article
Accés obertEchinocandins are the newest class of antifungal drugs in clinical use. These agents inhibit β-glucan synthase, which catalyzes the synthesis of β-glucan, an essential component of the fungal cell wall, and have a high ...