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Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres.
dc.contributor.author | Gil Mur, Francisco Javier |
dc.contributor.author | Rodríguez Contreras, Alejandra María |
dc.contributor.author | Ginebra Molins, Maria Pau |
dc.contributor.author | Canal Barnils, Cristina |
dc.contributor.author | Calafell Monfort, Margarita |
dc.contributor.author | Marqués Calvo, M. Soledad |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria |
dc.date.accessioned | 2015-04-23T10:51:37Z |
dc.date.created | 2013-08-10 |
dc.date.issued | 2013-08-10 |
dc.identifier.citation | Gil, F.J. [et al.]. Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres.. "European polymer journal", 10 Agost 2013, vol. 49, p. 3501-3511. |
dc.identifier.issn | 0014-3057 |
dc.identifier.uri | http://hdl.handle.net/2117/27548 |
dc.description.abstract | Natural and synthetic biodegradable polymers have been investigated for controlled drug release. Poly(3-hydroxybutyrate) can be produced by bacteria and is remarkable for this application due to its excellent biocompatibility and biodegradability. The objective of this work was to study different drug-entrapment and emulsification methods for the obtaining of doxycycline-loaded PHB micro- and nano-spheres. The micro-/nano-particles were prepared by polymer precipitation via dialysis, simple emulsion (O/W) or multiple emulsion (W1/O/W2) applying solvent evaporation in the last two cases. This was carried out either by ultrasonication, dripping and/or high speed stirring. Different processing conditions were varied in order to evaluate their influence on morphology, size, and drug entrapment capabilities. The highest drug loading was obtained by single emulsion with high speed stirring. In the case of multiple emulsion, the combination of ultrasound with high speed stirring resulted in the most elevate process yield and drug loading capability. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials::Materials plàstics i polímers |
dc.subject.lcsh | Composite materials |
dc.subject.lcsh | Polimers |
dc.subject.other | Drug delivery systems |
dc.subject.other | Micro- and nano-particles |
dc.subject.other | Doxycycline Poly(3-hydroxybutirate) |
dc.title | Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres. |
dc.type | Article |
dc.subject.lemac | Polímers |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.contributor.group | Universitat Politècnica de Catalunya. Càtedra A3 ENGIBIO - Càtedra A3 d’Innovació en Cuir, Moda i Tèxtils |
dc.contributor.group | Universitat Politècnica de Catalunya. TMAS (T+) - Toxicologia i Microbiologia Ambiental i Sanitària |
dc.identifier.doi | 10.1016/j.eurpolymj.2013.08.010 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 15592341 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Gil, F.J.; Rodriguez, A.; Ginebra, M.P.; Canal, C.; Calafell, M.; Marques, M.S. |
local.citation.publicationName | European polymer journal |
local.citation.volume | 49 |
local.citation.startingPage | 3501 |
local.citation.endingPage | 3511 |
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