Shape dynamics, lipid hydrodynamics, and the complex viscoelasticty of bilayer membranes
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Data publicació2012-07
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Abstract
Biological membranes are continuously brought out of equilibrium, as they shape organelles, package and
transport cargo, or respond to external actions. Even the dynamics of plain lipid membranes in experimental model
systems are very complex due to the tight interplay between the bilayer architecture, the shape dynamics, and the
rearrangement of the lipid molecules.We formulate and numerically implement a continuum model of the shape
dynamics and lipid hydrodynamics, which describes the bilayer by its midsurface and by a lipid density field for
each monolayer. The viscoelastic response of bilayers is determined by the stretching and curvature elasticity,
and by the inter-monolayer friction and the membrane interfacial shear viscosity. While the bilayer equilibria
are well understood theoretically, dynamical calculations have relied on simplified continuum approaches of
uncertain transferability, or on molecular simulations reaching very limited length and time scales. Our approach
incorporates the main physics, is fully nonlinear, does not assume predefined shapes, and can access a wide range
of time and length scales. We validate it with the well understood tether extension. We investigate the tubular
lipid transport between cells, the dynamics of bud absorption by a planar membrane, and the fate of a localized
lipid density asymmetry in vesicles. These axisymmetric examples bear biological relevance and highlight the
diversity of dynamical regimes that bilayers can experience.
CitacióRahimi, M.; Arroyo, M. Shape dynamics, lipid hydrodynamics, and the complex viscoelasticty of bilayer membranes. "Physical review E: statistical, nonlinear, and soft matter physics", Juliol 2012, vol. 86, núm. 1, p. 1-15.
ISSN1539-3755
Versió de l'editorhttp://pre.aps.org/abstract/PRE/v86/i1/e011932
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e011932.pdf | Article de revista | 2,147Mb | Accés restringit |