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A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women

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Pastor, Antoni
Fernández-Aranda, Fernando
Fitó, Montserrat
Jiménez-Murcia, Susana
Botella, Cristina
Fernández-Real, Jose M.
Frühbeck, Gema
Tinahones, Francisco
Fagundo, Ana
Rodriguez, Joan
Agüera, Zaida
Langohr, KlausMés informacióMés informacióMés informació
Casanueva, Felipe F.
de la Torre, Rafael
Document typeArticle
Defense date2016
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible interaction between olfaction, obesity and the eCB system. The study sample was made up of 161 females with five groups of body mass index sub-categories ranging from under-weight to morbidly obese. We assessed olfactory capacity with the “Sniffin´Sticks” test, which measures olfactory threshold-discrimination-identification (TDI) capacity. We measured plasma concentrations of the eCBs 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine or anandamide (AEA), and several eCB-related compounds, 2-acylglycerols and N-acylethanolamines. 2-AG and other 2-acylglycerols fasting plasma circulating plasma concentrations were higher in obese and morbidly obese subjects. AEA and other N-acylethanolamine circulating concentrations were lower in under-weight subjects. Olfactory TDI scores were lower in obese and morbidly obese subjects. Lower TDI scores were independently associated with higher 2-AG fasting plasma circulating concentrations, higher %body fat, and higher body mass index, after controlling for age, smoking, menstruation, and use of contraceptives. Our results show that obese subjects have a lower olfactory capacity than non-obese ones and that elevated fasting plasma circulating 2-AG concentrations in obesity are linked to a lower olfactory capacity. In agreement with previous studies we show that eCBs AEA and 2-AG, and their respective congeners have a distinct profile in relation to body mass index. The present report is the first study in humans in which olfactory capacity and circulating eCB concentrations have been measured in the same subjects.
CitationPastor, A., Fernández-Aranda, F., Fitó, M., Jiménez-Murcia, S., Botella, C., Fernández-Real, J., Frühbeck, G., Tinahones, F., Fagundo, A., Rodriguez, J., Agüera, Z., Langohr, K., Casanueva, F., de la Torre, R. A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women. "PLoS one", 2016, vol. 11, núm. 2, p. 1-15. 
URIhttp://hdl.handle.net/2117/99399
DOI10.1371/journal.pone.0148734
ISSN1932-6203
Publisher versionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148734
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  • Departament d'Estadística i Investigació Operativa - Articles de revista [628]
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