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dc.contributor.authorSachot, Nadège
dc.contributor.authorCastaño Linares, Óscar
dc.contributor.authorOliveira, Hugo
dc.contributor.authorMartí Muñoz, Joan
dc.contributor.authorRoguska, Agata
dc.contributor.authorAmedee, Joelle
dc.contributor.authorLewandowska, Malgorzata
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2016-12-14T10:18:02Z
dc.date.available2016-12-14T10:18:02Z
dc.date.issued2016-11-02
dc.identifier.citationSachot, N., Castaño, O., Oliveira, H., Martí-Muñoz, J., Roguska, A., Amedee, J., Lewandowska, M., Planell, J., Engel, E. A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis. "Journal of materials chemistry B", 2 Novembre 2016, vol. 4, p. 6967-6978.
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/2117/98197
dc.description.abstractAlthough the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of polylactic acid (PLA) and a microparticle glass of 5TiO 2 –44.5CaO–44.5P 2 O 5 –6Na 2 O (G5) molar ratio have already demonstrated in situ osteo- and angiogenesis-triggering abilities. As many of the hybrid materials currently developed usually promote osteogenesis but still lack the ability to induce vascularization, a G5/PLA combination is a cost-effective option for obtaining new instructive scaffolds. In this study, nanostructured PLA-ORMOGLASS (organically modified glass) fibers were produced by electro- spinning, in order to fabricate extra-cellular matrix (ECM)-like substrates that simultaneously promote bone formation and vascularization. Physical–chemical and surface characterization and tensile tests demon- strated that the obtained scaffolds exhibited homogeneous morphology, higher hydrophilicity and enhanced mechanical properties than pure PLA. In vitro assays with rat mesenchymal stem cells (rMSCs) and rat endothelial progenitor cells (rEPCs) also showed that rMSCs attached and proliferated on the materials influenced by the calcium content in the environment. In vivo assays showed that hybrid composite PLA-ORMOGLASS fibers were able to promote the formation of blood vessels. Thus, these novel fibers are a valid option for the design of functional materials for tissue engineering applications
dc.format.extent12 p.
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTissue engineering
dc.subject.lcshBiomedical materials
dc.subject.lcshNanostructured materials
dc.titleA novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis
dc.typeArticle
dc.subject.lemacEnginyeria de teixits
dc.subject.lemacMaterials biomèdics
dc.subject.lemacMaterials nanoestructurats
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1039/C6TB02162J
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
local.identifier.drac19257293
dc.description.versionPostprint (published version)
local.citation.authorSachot, N.; Castaño, O.; Oliveira, H.; Martí-Muñoz, J.; Roguska, A.; Amedee, J.; Lewandowska, M.; Planell, J.; Engel, E.
local.citation.publicationNameJournal of materials chemistry B
local.citation.volume4
local.citation.startingPage6967
local.citation.endingPage6978


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