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dc.contributor.authorVila, Mercedes
dc.contributor.authorGarcía, Ana
dc.contributor.authorGirotti, Alessandra
dc.contributor.authorAlonso, Matilde
dc.contributor.authorRodriguez Cabello, Jose Carlos
dc.contributor.authorGonzalez Vazquez, Arlyng
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorEngel López, Elisabeth
dc.contributor.authorBuján, Julia
dc.contributor.authorGarcía Honduvilla, Natalio
dc.contributor.authorVallet Regi, Maria
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2016-12-14T09:34:46Z
dc.date.available2018-11-01T01:30:26Z
dc.date.issued2016-11-01
dc.identifier.citationVila, M., García, A., Girotti, A., Alonso, M., Rodriguez-Cabello , J.C., Gonzalez, A., Planell, J., Engel, E., Buján, J., García, N., Vallet-Regi, M. 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine. "Acta biomaterialia", 1 Novembre 2016, vol. 45, p. 349-356.
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/2117/98193
dc.description.abstractThe current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) functionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineering: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxyapatite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible and bone regeneration properties of calcium phosphates materials. The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts.
dc.format.extent8 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTissue engineering
dc.subject.lcshRegenerative medicine
dc.subject.lcshBiomedical materials
dc.subject.otherBone repair
dc.subject.othertissue engineering
dc.subject.otherElastin-like Recombinamers (ELRs)
dc.subject.otherSilicon doped hydroxyapatite (Si-HA)
dc.subject.otherrapid prototyped 3D scaffolds
dc.subject.otherBone marrow Mesenchymal Stromal Cells (BMSCs)
dc.title3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
dc.typeArticle
dc.subject.lemacEnginyeria de teixits
dc.subject.lemacMedicina regenerativa
dc.subject.lemacMaterials biomèdics
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.actbio.2016.09.016
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1742706116304792
dc.rights.accessOpen Access
local.identifier.drac19257193
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/278557/EU/Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer/THE GRAIL
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/646075/EU/Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet%2FCell Niche/ELASTISLET
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/642687/EU/Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications/BIOGEL
local.citation.authorVila, M.; García, A.; Girotti, A.; Alonso, M.; Rodriguez-Cabello, J.C.; Gonzalez, A.; Planell, J.; Engel, E.; Buján, J.; García, N.; Vallet-Regi, M.
local.citation.publicationNameActa biomaterialia
local.citation.volume45
local.citation.startingPage349
local.citation.endingPage356


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