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dc.contributor.authorPappalardo, Morena
dc.contributor.authorJuliá, Miguel
dc.contributor.authorHoward, Mark J.
dc.contributor.authorRossman, Jeremy S.
dc.contributor.authorMichaelis, Martin
dc.contributor.authorWass, Mark N.
dc.date.accessioned2016-10-26T12:12:51Z
dc.date.available2016-10-26T12:12:51Z
dc.date.issued2015-05-05
dc.identifier.citationPappalardo, Morena [et al.]. Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses. A: 3rd BSC International Doctoral Symposium. "Book of abstracts". Barcelona: Barcelona Supercomputing Center, 2015, p. 114-120.
dc.identifier.urihttp://hdl.handle.net/2117/91108
dc.description.abstractThis work describes the analysis of 196 Ebolavirus genomes and the identification of specificity determining positions (SDPs) in all nine Ebolavirus proteins that distinguish the non human pathogenic Reston viruses from the four human pathogenic Ebolaviruses. Structural analysis was performed to identify those SDPs that are likely to have a functional effect. This analysis revealed novel functional insights, in particular for Ebolavirus proteins VP40 and VP24. The VP40 SDP P85T interferes with VP40 function by altering octamer formation. The VP40 SDP Q245P affects the structure and hydrophobic core of the protein and consequently protein function. Three VP24 SDPs (T131S, M136L, Q139R) are likely to impair VP24 binding to human karyopherin alpha5 (KPNA5) and therefore inhibition of interferon signaling. Since VP24 is critical for Ebolavirus adaptation to novel hosts, and only a few SDPs distinguish Reston virus VP24 from VP24 of other Ebolaviruses, human pathogenic Reston viruses may emerge
dc.format.extent7 p.
dc.language.isoeng
dc.publisherBarcelona Supercomputing Center
dc.relation.ispartofBSC International Doctoral Symposium (3rd: 2016: Barcelona)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Informàtica::Arquitectura de computadors
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina
dc.subject.lcshHigh performance computing
dc.subject.lcshEbola virus disease
dc.subject.lcshViral genetics
dc.subject.otherSpecificity determining positions
dc.subject.otherEbolavirus
dc.subject.otherSDPs
dc.subject.otherReston viruses
dc.subject.otherEbola viruses
dc.subject.otherSudan viruses
dc.subject.otherBundibugyo viruses
dc.subject.otherTaϊ Forest viruses
dc.titleConserved differences in protein sequence determine the human pathogenicity of Ebolaviruses
dc.typeConference report
dc.subject.lemacCàlcul intensiu (Informàtica)
dc.subject.lemacMalaltia de l'Ebola
dc.subject.lemacGenètica vírica
dc.rights.accessOpen Access
local.citation.contributor3rd BSC International Doctoral Symposium
local.citation.pubplaceBarcelona
local.citation.publicationNameBook of abstracts
local.citation.startingPage114
local.citation.endingPage120
dc.identifier.pmid27009368


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