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dc.contributor.authorLópez-Ferrando, Victor
dc.contributor.authorCruz, Xavier de la
dc.contributor.authorOrozco, Modesto
dc.contributor.authorGelpí, Josep Lluís
dc.date.accessioned2016-10-26T12:12:40Z
dc.date.available2016-10-26T12:12:40Z
dc.date.issued2015-05-05
dc.identifier.citationLópez-Ferrando, Victor [et al.]. PMut2: a web-based tool for predicting pathological mutations on proteins. A: 3rd BSC International Doctoral Symposium. "Book of abstracts". Barcelona Supercomputing Center, 2015, p. 127-129.
dc.identifier.urihttp://hdl.handle.net/2117/91107
dc.description.abstractAmino acid substitutions in proteins can result in an altered phenotype which might lead to a disease. PMut2 is a method that can predict whether a mutation has a pathological effect on the protein function. It uses current machine learning algorithms based on protein sequence derived information. The accuracy of PMut2 is as high as 82%, with a Matthews correlation coefficient of 0,62. PMut2 predictions can be obtained through a modern website which also allows to apply the same machine learning methodology that is used to train PMut2 to custom training sets, allowing users to build their own tailor-made predictors.
dc.format.extent3 p.
dc.language.isoeng
dc.publisherBarcelona Supercomputing Center
dc.relation.ispartofBSC International Doctoral Symposium (3rd: 2016: Barcelona)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Informàtica::Arquitectura de computadors
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina
dc.subject.lcshHigh performance computing
dc.subject.lcshAmino acid sequence
dc.subject.lcshProteins
dc.subject.lcshVariació (Biologia)
dc.subject.otherPMut2
dc.titlePMut2: a web-based tool for predicting pathological mutations on proteins
dc.typeConference report
dc.subject.lemacCàlcul intensiu (Informàtica)
dc.subject.lemacSeqüència d'aminoàcids
dc.subject.lemacProteïnes
dc.subject.lemacMutació (Biologia)
dc.rights.accessOpen Access
upcommons.citation.contributor3rd BSC International Doctoral Symposium
upcommons.citation.publishedtrue
upcommons.citation.publicationNameBook of abstracts
upcommons.citation.startingPage127
upcommons.citation.endingPage129


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