Effects of thermoregulation on human sleep patterns: A mathematical model of sleep-wake cycles with REM-NREM subcircuit
Document typePart of book or chapter of book
Rights accessOpen Access
In this paper we construct a mathematical model of human sleep/wake regulation with thermoregulation and temperature e ects. Simulations of this model show features previously presented in experimental data such as elongation of duration and number of REM bouts across the night as well as the appearance of awakenings due to deviations in body temperature from thermoneutrality. This model helps to demonstrate the importance of temperature in the sleep cycle. Further modi cations of the model to include more temperature e ects on other aspects of sleep regulation such as sleep and REM latency are discussed
CitationBañuelos, S., Best, J., Huguet, G., Prieto-Langarica, A., Pyzza, P. B., Schmidt, M. H., Wilson, S. Effects of thermoregulation on human sleep patterns: A mathematical model of sleep-wake cycles with REM-NREM subcircuit. A: "Applications of dynamical systems in biology and medicine". 2015.