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dc.contributor.authorMacedo Fernandes, Margarida Maria
dc.contributor.authorIvanova, Kristina Dimitrova
dc.contributor.authorFrancesko, Antonio
dc.contributor.authorRivera, Diana
dc.contributor.authorTorrent Burgués, Juan
dc.contributor.authorMendoza Gómez, Ernesto
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2016-09-21T11:43:01Z
dc.date.available2017-10-03T00:30:10Z
dc.date.issued2016-06-09
dc.identifier.citationMacedo, M.M., Ivanova, K., Francesko, A., Rivera, D., Torrent, J.; Torrent-Burgués, J., Mendoza, E., Tzanov, T. Escherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G. "Nanomedicine: nanotechnology, biology and medicine", 9 Juny 2016, vol. 12, núm. 7, p. 2061-2069.
dc.identifier.issn1549-9634
dc.identifier.urihttp://hdl.handle.net/2117/90102
dc.description.abstractThe transformation of penicillin G into nano/micro-sized spheres (nanopenicillin) using sonochemical technology was explored as a novel tool for the eradication of Gram-negative bacteria and their biofilms. Known by its effectiveness only against Gram-positive microorganisms, the penicillin G spherization boosted the inhibition of the Gram-negative Pseudomonas aeruginosa 10-fold (from 0.3 to 3.0 log-reduction) and additionally induced 1.2 log-reduction of Escherichia coli growth. The efficient penetration of the spheres within a Langmuir monolayer sustained the theory that nanopenicillin is able to cross the membrane and reach the periplasmic space in Gram-negative bacteria where they inhibit the ß-lactam targets: the transferases that build the bacteria cell wall. Moreover, it considerably suppressed the growth of both bacterial biofilms on a medically relevant polystyrene surface, leaving majority of the adhered cells dead compared to the treatment with the non-processed penicillin G. Importantly, nanopenicillin was found innocuous towards human fibroblasts at the antibacterial-effective concentration
dc.format.extent9 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshBioengineering
dc.subject.lcshNanoparticles--Therapeutic use
dc.subject.otherPenicillin G
dc.subject.otherSonochemistry
dc.subject.otherNano/Microspheres
dc.subject.otherNano-bio interactions
dc.subject.otherAntibacterial
dc.subject.otherAntibiofilm
dc.titleEscherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G
dc.typeArticle
dc.subject.lemacBioenginyeria
dc.subject.lemacNanopartícules -- Ús terapèutic
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1016/j.nano.2016.05.018
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.nanomedjournal.com/article/S1549-9634(16)30065-X/abstract
dc.rights.accessOpen Access
drac.iddocument18768186
dc.description.versionPostprint (published version)
upcommons.citation.authorMacedo, M.M., Ivanova, K., Francesko, A., Rivera, D., Torrent, J.; Torrent-Burgués, J., Mendoza, E., Tzanov, T.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameNanomedicine: nanotechnology, biology and medicine
upcommons.citation.volume12
upcommons.citation.number7
upcommons.citation.startingPage2061
upcommons.citation.endingPage2069


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