Influence of gap junction dynamics on the stability of reentrant waves in cadiac tissue

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Document typeConference report
Defense date2015
Rights accessOpen Access
Abstract
Constant conductances are often assumed when model-
ing cardiac tissue. However experimental evidences have
shown that gap junctions (GJ) actually connect adjacent
cardiac myocytes. These GJ are complex proteins of the
connexin family (Cx40; Cx43; Cx45 are the most common
in human). These GJ modify the conductances between
cardiac cell through a dynamical process. The aim of this
study is to develop a bidomain model of the cardiac tis-
sue where the dynamics of the connexins is also included.
In particular we will compare the differences associated
with the use of a monodomain versus bidomain formula-
tion in inducing intra-cellular conductance variations. We
have found that the monodomain formulation gives con-
ductance variations a factor four to five larger with respect
to the bidomain formulation
CitationHawks, C., Elorza, J., Echebarria, B., Rodriguez Cantalapiedra, I., Peñaranda, A., Bragard, J. Influence of gap junction dynamics on the stability of reentrant waves in cadiac tissue. A: Computing in Cardiology Annual Conference. "Computing in Cardiology 42, 2015". Niza: 2015, p. 437-440.
ISBN0276-6574
Publisher versionhttp://www.cinc.org/archives/2015/pdf/0437.pdf
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