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Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications
dc.contributor.author | Rodriguez Contreras, Alejandra |
dc.contributor.author | Marqués Calvo, M. Soledad |
dc.contributor.author | Gil Mur, Francisco Javier |
dc.contributor.author | Manero Planella, José María |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2016-09-19T09:55:04Z |
dc.date.available | 2016-09-19T09:55:04Z |
dc.date.issued | 2016-08-01 |
dc.identifier.citation | Rodriguez , A., Marques, M.S., Gil, J., Manero, J. Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications. "Journal of materials science. Materials in medicine", 1 Agost 2016, vol. 27, núm. 8. |
dc.identifier.issn | 0957-4530 |
dc.identifier.uri | http://hdl.handle.net/2117/90018 |
dc.description.abstract | Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano-and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Cirurgia |
dc.subject.lcsh | Titanium |
dc.subject.lcsh | Nanoparticles |
dc.subject.lcsh | Metals--Heat treatment |
dc.subject.lcsh | Surgery--Complications |
dc.subject.lcsh | Implants, Artificial |
dc.subject.other | HEAT-TREATMENTS |
dc.subject.other | TI |
dc.subject.other | NANOPARTICLES |
dc.subject.other | POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE) |
dc.subject.other | 3-AMINOPROPYLTRIETHOXYSILANE |
dc.subject.other | INFECTIONS |
dc.subject.other | ADHESION |
dc.subject.other | ACID |
dc.title | Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications |
dc.type | Article |
dc.subject.lemac | Titani |
dc.subject.lemac | Nanopartícules |
dc.subject.lemac | Metalls -- Tractament tèrmic |
dc.subject.lemac | Implants artificials |
dc.subject.lemac | Cirurgia -- Complicacions |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1007/s10856-016-5723-4 |
dc.rights.access | Open Access |
local.identifier.drac | 18570727 |
dc.description.version | Postprint (author's final draft) |
dc.relation.projectid | info:eu-repo/grantAgreement/MINECO//MAT2012-30706/ES/NUEVOS BIOMATERIALES METALICOS BIOFUNCIONALIZADOS PARA APLICACIONES ORTOPEDICAS, DENTALES Y CARDIOVASCULARES/ |
local.citation.author | Rodriguez, A.; Marques, M.S.; Gil, J.; Manero, J. |
local.citation.publicationName | Journal of materials science. Materials in medicine |
local.citation.volume | 27 |
local.citation.number | 8 |
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