Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications
Visualitza/Obre
Cita com:
hdl:2117/90018
Tipus de documentArticle
Data publicació2016-08-01
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano-and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent.
CitacióRodriguez , A., Marques, M.S., Gil, J., Manero, J. Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications. "Journal of materials science. Materials in medicine", 1 Agost 2016, vol. 27, núm. 8.
ISSN0957-4530
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
10856_2016_5723_Author.pdf | 3,616Mb | Visualitza/Obre |