Ir al contenido (pulsa Retorno)

Universitat Politècnica de Catalunya

    • Català
    • Castellano
    • English
    • LoginRegisterLog in (no UPC users)
  • mailContact Us
  • world English 
    • Català
    • Castellano
    • English
  • userLogin   
      LoginRegisterLog in (no UPC users)

UPCommons. Global access to UPC knowledge

Banner header
68.742 UPC E-Prints
You are here:
View Item 
  •   DSpace Home
  • E-prints
  • Departaments
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
  • Articles de revista
  • View Item
  •   DSpace Home
  • E-prints
  • Departaments
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
  • Articles de revista
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Design of calcium phosphate scaffolds with controlled simvastatin release by plasma polymerisation

Thumbnail
View/Open
POLYMER postprints Canal.pdf (1,123Mb)
 
10.1016/j.polymer.2016.03.069
 
  View UPCommons Usage Statistics
  LA Referencia / Recolecta stats
Includes usage data since 2022
Cita com:
hdl:2117/89972

Show full item record
Canal Barnils, CristinaMés informacióMés informacióMés informació
Khurana, Kanupriya
Gallinetti, Sara
Bhatt, Sudhir
Pulpytel, Jerome
Arefi Khonsari, Farzaneh
Ginebra Molins, Maria PauMés informacióMés informacióMés informació
CovenanteeUniversité Pierre et Marie Curie; Universitat Autònoma de Barcelona
Document typeArticle
Defense date2016-06-01
PublisherElsevier
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Calcium Phosphates (CaPs) have excellent bone regeneration capacity, and their combination with specific drugs is of interest because it allows adding new functionalities. In CaPs, drug release is mainly driven by diffusion, which is strongly affected by the porosity of the matrix and the drug-material interaction. Therefore, it is very difficult to tune their drug release properties beyond their intrinsic properties. Furthermore, when the CaPs are designed as scaffolds, the increased complexity of the macrostructure further complicates the issue.; This work investigates for the first time the use of biocompatible plasma-polymers to provide a tool to control drug release from drug-loaded CaP scaffolds with complex surfaces and intricate 3D structure. Two different CaPs were selected displaying great differences in microstructure: low-temperature CaPs (Calcium-deficient hydroxyapatite cements, CDHA) and sintered CaP ceramics (beta-Tricalcium Phosphate, beta-TCP). The deposition of PCL-co-PEG (1: 4) copolymers on CaPs was achieved by a low pressure plasma process, which allowed coating the inner regions of the scaffolds up to a certain depth. The coating covered the micro and nanopores of the CaPs surface and produced complex geometries presenting a nano and micro rough morphology which lead to low wettability despite the hydrophilicity of the copolymer. Plasma coating with PCL-co-PEG on scaffolds loaded with Simvastatin acid (potentially osteogenic and angiogenic) allowed delaying and modulating the drug release from the bone scaffolds depending on the thickness of the layer deposited, which, in turn depends on the initial specific surface area of the CaP. (C) 2016 Elsevier Ltd. All rights reserved.
CitationCanal, C., Khurana, K., Gallinetti, S., Bhatt, S., Pulpytel, J., Arefi, F., Ginebra, M.P. Design of calcium phosphate scaffolds with controlled simvastatin release by plasma polymerisation. "Polymer", 1 Juny 2016, vol. 92, p. 170-178. 
URIhttp://hdl.handle.net/2117/89972
DOI10.1016/j.polymer.2016.03.069
ISSN0032-3861
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0032386116302166
Collections
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [960]
  • BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [478]
  View UPCommons Usage Statistics

Show full item record

FilesDescriptionSizeFormatView
POLYMER postprints Canal.pdf1,123MbPDFView/Open

Browse

This CollectionBy Issue DateAuthorsOther contributionsTitlesSubjectsThis repositoryCommunities & CollectionsBy Issue DateAuthorsOther contributionsTitlesSubjects

© UPC Obrir en finestra nova . Servei de Biblioteques, Publicacions i Arxius

info.biblioteques@upc.edu

  • About This Repository
  • Metadata under:Metadata under CC0
  • Contact Us
  • Send Feedback
  • Privacy Settings
  • Inici de la pàgina