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dc.contributor.authorPérez Madrigal, Maria del Mar
dc.contributor.authorLlorens, Elena
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorPuiggalí Bellalta, Jordi
dc.contributor.authorArmelín Diggroc, Elaine Aparecida
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2016-09-14T11:11:05Z
dc.date.available2016-09-14T11:11:05Z
dc.date.issued2016-02-25
dc.identifier.citationPérez-Madrigal, M.M., Llorens, E., del Valle, LJ., Puiggali, J., Armelin, E., Aleman, C. Semiconducting, biodegradable and bioactive fibers for drug delivery. "Express polymer letters", 25 Febrer 2016, vol. 10, núm. 8, p. 628-646.
dc.identifier.issn1788-618X
dc.identifier.urihttp://hdl.handle.net/2117/89911
dc.description.abstract© BME-PT. In this work we present the drug release properties and morphological studies of fibers formed by mixing different ratios of poly(lactic acid) (PLA) and poly(3-thiophene methyl acetate) (P3TMA) loaded with four drugs (ciprofloxacin, chlorhexidine dihydrochloride, triclosan and ibuprofen sodium salt). Thus, the main aim of this study is to prove that the excellent cellular response of PLA-P3TMA biocompatible scaffolds can be successfully combined with essential applications as drug carrier and delivery systems. Atomic force microscopic (AFM) and scanning electron microscopic (SEM) micro-graphs of PLA-P3TMA fibers indicate that the presence of the conducting polymer inside the PLA matrix affects the surface morphology, resulting in a significant increment of the bulk conductivity with respect to PLA fibers. Electrospun hybrid fibers of PLA and P3TMA successfully load both hydrophilic and hydrophobic drugs, the release profiles depending on the release environment (i.e. the release rate increases with the hydrophobicity of the medium). Finally, our results prove that the antibacterial activity of the drugs is not affected by their interactions with the PLA-P3TMA matrix.
dc.format.extent19 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshBiopolymers
dc.subject.lcshConducting polymers
dc.subject.lcshNanotechnology
dc.subject.otherAtomic force microscopy (AFM)
dc.subject.otherBiocomposites
dc.subject.otherBiopolymers
dc.subject.otherConducting polymers
dc.subject.otherDrug delivery systems
dc.subject.otherNanotechnology
dc.titleSemiconducting, biodegradable and bioactive fibers for drug delivery
dc.typeArticle
dc.subject.lemacPolímers conductors
dc.subject.lemacBiopolímers
dc.subject.lemacNanotecnologia
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM - Innovació, Modelització i Enginyeria en (BIO) Materials
dc.identifier.doi10.3144/expresspolymlett.2016.58
dc.rights.accessOpen Access
local.identifier.drac18711851
dc.description.versionPostprint (published version)
local.citation.authorPérez-Madrigal, M.M.; Llorens, E.; del Valle, LJ.; Puiggali, J.; Armelin, E.; Aleman, C.
local.citation.publicationNameExpress polymer letters
local.citation.volume10
local.citation.number8
local.citation.startingPage628
local.citation.endingPage646


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