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dc.contributor.authorRodríguez Cantalapiedra, Inma
dc.contributor.authorPeñaranda Ayllón, Angelina
dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.authorBragard, Jean
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física Aplicada
dc.date.accessioned2010-09-21T10:38:21Z
dc.date.available2010-09-21T10:38:21Z
dc.date.created2010-07-13
dc.date.issued2010-07-13
dc.identifier.citationRodríguez Cantalapiedra, I. [et al.]. Phase-2 reentry in cardiac tissue: role of the slow calcium pulse. "Physical review E, statistical physics, plasmas, fluids, and related interdisciplinary topics", 13 Juliol 2010, vol. 82, núm. 1, p. 1907.
dc.identifier.issn1063-651X
dc.identifier.urihttp://hdl.handle.net/2117/8989
dc.description.abstractPhase-2 re-entry is thought to underlie many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. In this paper, we study under which circumstances a region of depolarized tissue can re-excite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. For this purpose, we use a simplified ionic model that reproduces well the ventricular action potential. With the help of this model, we analyze the conditions that lead to very short action potentials (APs), as well as possible mechanisms for re-excitation in a cable. We then study the induction of re-entrant waves (spiral waves) in simulations of AP propagation in the heart ventricles. We show that re-excitation takes place via a slow pulse produced by calcium current that propagates into the region of short APs until it encounters excitable tissue. We calculate analytically the speed of the slow pulse, and also give an estimate of the minimal tissue size necessary for allowing reexcitation to take place.
dc.format.extent1 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials::Materials funcionals::Materials elèctrics i electrònics
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Equacions diferencials i integrals::Sistemes dinàmics
dc.subject.lcshPulse--Measurement
dc.subject.lcshDifferential equations, Nonlinear
dc.titlePhase-2 reentry in cardiac tissue: role of the slow calcium pulse
dc.typeArticle
dc.subject.lemacMaterials -- Models matemàtics
dc.contributor.groupUniversitat Politècnica de Catalunya. NOLIN - Física No-Lineal i Sistemes Fora de l'Equilibri
dc.identifier.doi10.1103/PhysRevE.82.011907
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://pre.aps.org/abstract/PRE/v82/i1/e011907
dc.rights.accessOpen Access
drac.iddocument2603926
dc.description.versionPostprint (published version)
upcommons.citation.authorRodríguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.; Bragard, J.
upcommons.citation.publishedtrue
upcommons.citation.publicationNamePhysical review E, statistical physics, plasmas, fluids, and related interdisciplinary topics
upcommons.citation.volume82
upcommons.citation.number1
upcommons.citation.startingPage1907
upcommons.citation.endingPage1907


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Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain