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Phase-2 reentry in cardiac tissue: role of the slow calcium pulse
dc.contributor.author | Rodríguez Cantalapiedra, Inma |
dc.contributor.author | Peñaranda Ayllón, Angelina |
dc.contributor.author | Echebarría Domínguez, Blas |
dc.contributor.author | Bragard, Jean |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física Aplicada |
dc.date.accessioned | 2010-09-21T10:38:21Z |
dc.date.available | 2010-09-21T10:38:21Z |
dc.date.created | 2010-07-13 |
dc.date.issued | 2010-07-13 |
dc.identifier.citation | Rodríguez Cantalapiedra, I. [et al.]. Phase-2 reentry in cardiac tissue: role of the slow calcium pulse. "Physical review E, statistical physics, plasmas, fluids, and related interdisciplinary topics", 13 Juliol 2010, vol. 82, núm. 1, p. 1907. |
dc.identifier.issn | 1063-651X |
dc.identifier.uri | http://hdl.handle.net/2117/8989 |
dc.description.abstract | Phase-2 re-entry is thought to underlie many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. In this paper, we study under which circumstances a region of depolarized tissue can re-excite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. For this purpose, we use a simplified ionic model that reproduces well the ventricular action potential. With the help of this model, we analyze the conditions that lead to very short action potentials (APs), as well as possible mechanisms for re-excitation in a cable. We then study the induction of re-entrant waves (spiral waves) in simulations of AP propagation in the heart ventricles. We show that re-excitation takes place via a slow pulse produced by calcium current that propagates into the region of short APs until it encounters excitable tissue. We calculate analytically the speed of the slow pulse, and also give an estimate of the minimal tissue size necessary for allowing reexcitation to take place. |
dc.format.extent | 1 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials::Materials funcionals::Materials elèctrics i electrònics |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Equacions diferencials i integrals::Sistemes dinàmics |
dc.subject.lcsh | Pulse--Measurement |
dc.subject.lcsh | Differential equations, Nonlinear |
dc.title | Phase-2 reentry in cardiac tissue: role of the slow calcium pulse |
dc.type | Article |
dc.subject.lemac | Materials -- Models matemàtics |
dc.contributor.group | Universitat Politècnica de Catalunya. NOLIN - Física No-Lineal i Sistemes Fora de l'Equilibri |
dc.identifier.doi | 10.1103/PhysRevE.82.011907 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://pre.aps.org/abstract/PRE/v82/i1/e011907 |
dc.rights.access | Open Access |
local.identifier.drac | 2603926 |
dc.description.version | Postprint (published version) |
local.citation.author | Rodríguez Cantalapiedra, I.; Peñaranda, A.; Echebarria, B.; Bragard, J. |
local.citation.publicationName | Physical review E, statistical physics, plasmas, fluids, and related interdisciplinary topics |
local.citation.volume | 82 |
local.citation.number | 1 |
local.citation.startingPage | 1907 |
local.citation.endingPage | 1907 |
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