Phase-2 reentry in cardiac tissue: role of the slow calcium pulse
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hdl:2117/8989
Tipus de documentArticle
Data publicació2010-07-13
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Abstract
Phase-2 re-entry is thought to underlie many causes of idiopathic ventricular arrhythmias as, for instance,
those occurring in Brugada syndrome. In this paper, we study under which circumstances a region of depolarized
tissue can re-excite adjacent regions that exhibit shorter action potential duration (APD), eventually
inducing reentry. For this purpose, we use a simplified ionic model that reproduces well the ventricular action
potential. With the help of this model, we analyze the conditions that lead to very short action potentials (APs),
as well as possible mechanisms for re-excitation in a cable. We then study the induction of re-entrant waves
(spiral waves) in simulations of AP propagation in the heart ventricles. We show that re-excitation takes place
via a slow pulse produced by calcium current that propagates into the region of short APs until it encounters
excitable tissue. We calculate analytically the speed of the slow pulse, and also give an estimate of the minimal
tissue size necessary for allowing reexcitation to take place.
CitacióRodríguez Cantalapiedra, I. [et al.]. Phase-2 reentry in cardiac tissue: role of the slow calcium pulse. "Physical review E, statistical physics, plasmas, fluids, and related interdisciplinary topics", 13 Juliol 2010, vol. 82, núm. 1, p. 1907.
ISSN1063-651X
Versió de l'editorhttp://pre.aps.org/abstract/PRE/v82/i1/e011907
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