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Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells
dc.contributor.author | Hernadez-Hernandez, Gonzalo |
dc.contributor.author | Álvarez Lacalle, Enrique |
dc.contributor.author | Shiferaw, Yohannes |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física |
dc.date.accessioned | 2016-04-26T10:17:16Z |
dc.date.available | 2016-04-26T10:17:16Z |
dc.date.issued | 2015-11-20 |
dc.identifier.citation | Hernadez-Hernandez, G., Alvarez-Lacalle, E., Shiferaw, Y. Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells. "Physical review E: statistical, nonlinear, and soft matter physics", 20 Novembre 2015, vol. 92, núm. 052715. |
dc.identifier.issn | 1539-3755 |
dc.identifier.uri | http://hdl.handle.net/2117/86187 |
dc.description.abstract | Spontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac arrhythmias. However, to date, it is not understood what determines the timing and location of spontaneous calcium waves within cells. Here, we analyze a simplified model of SCR in which calcium release is modeled as a stochastic processes on a two-dimensional network of randomly distributed sites. Using this model we identify the essential parameters describing the system and compute the phase diagram. In particular, we identify a critical line which separates pinned and propagating fronts, and show that above this line wave nucleation is governed by fluctuations and the spatial connectivity of calcium release units. Using a mean-field analysis we show that the sites of wave nucleation are predicted by localized eigenvectors of a matrix representing the network connectivity of release sites. This result provides insight on the interplay between connectivity and fluctuations in the genesis of SCR in cardiac myocytes |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica |
dc.subject.lcsh | Calcium ions |
dc.subject.lcsh | Arrhythmias, Cardiac--physiopathology |
dc.title | Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells |
dc.type | Article |
dc.subject.lemac | Arrítmia |
dc.contributor.group | Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos |
dc.identifier.doi | 10.1103/PhysRevE.92.052715 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://journals.aps.org/pre/abstract/10.1103/PhysRevE.92.052715 |
dc.rights.access | Open Access |
local.identifier.drac | 17426905 |
dc.description.version | Postprint (published version) |
dc.relation.projectid | National Heart, Lung, and Blood Institute Grant No. RO1HL101196. |
dc.relation.projectid | info:eu-repo/grantAgreement/MICINN//FIS2011-28820-C02-01/ES/MODELIZACION DE DINAMICA CARDIACA A DISTINTAS ESCALAS/ |
local.citation.author | Hernadez-Hernandez, G.; Alvarez-Lacalle, E.; Shiferaw, Y. |
local.citation.publicationName | Physical review E: statistical, nonlinear, and soft matter physics |
local.citation.volume | 92 |
local.citation.number | 052715 |
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