Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells
Cita com:
hdl:2117/86187
Tipus de documentArticle
Data publicació2015-11-20
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Spontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium
waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac
arrhythmias. However, to date, it is not understood what determines the timing and location of spontaneous
calcium waves within cells. Here, we analyze a simplified model of SCR in which calcium release is modeled as
a stochastic processes on a two-dimensional network of randomly distributed sites. Using this model we identify
the essential parameters describing the system and compute the phase diagram. In particular, we identify a critical
line which separates pinned and propagating fronts, and show that above this line wave nucleation is governed by
fluctuations and the spatial connectivity of calcium release units. Using a mean-field analysis we show that the
sites of wave nucleation are predicted by localized eigenvectors of a matrix representing the network connectivity
of release sites. This result provides insight on the interplay between connectivity and fluctuations in the genesis
of SCR in cardiac myocytes
CitacióHernadez-Hernandez, G., Alvarez-Lacalle, E., Shiferaw, Y. Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells. "Physical review E: statistical, nonlinear, and soft matter physics", 20 Novembre 2015, vol. 92, núm. 052715.
ISSN1539-3755
Versió de l'editorhttp://journals.aps.org/pre/abstract/10.1103/PhysRevE.92.052715
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Alvarez Role.pdf | 3,318Mb | Visualitza/Obre | ||
Alvarez Role.pdf | 3,318Mb | Visualitza/Obre | ||
Alvarez Role.pdf | 3,318Mb | Visualitza/Obre |