Previously, our research group obtained a set of calibration equations for being used by an electricalimpedance tomograph (EIT). All equations transform the impedance changes into a measurable volumesignal in a group of healthy males. The performance of EIT, using these equations, was acceptable forrespiration monitoring. The EIT impedance changes were obtained from a set of 16-electrodes placedaround the thoracic box at level of the sixth intercostal space. Each cycle of impedance measurementsis ordered in a matrix (IEITM). Each IEITM’s element depicts a configuration of 4-electrodes. Now, ourmain challenge is to replace the EIT’s 16-electrodes by a 4-electrodes configuration. We analyzed theimpedance changes obtained from each element and the volume determinations obtained by a pneu-motachometer (gold standard) in order to determine the optimal 4-electrodes configuration. For eachselected configuration a set of 20 calibration equations were obtained. The best results were obtained byusing two 4-electrodes configurations. Both consisting in two adjacent electrodes for current injectionand two electrodes for voltage detection.The mean R2of the 20 equations determined by the 16-electrodes information, and for the best two 4-electrode configurations were 0.943 ± 0.010, 0.848 ± 0.062 and 0.690 ± 0.122, respectively. The error (%)of volume determinations obtained by the use of 16-electrodes, and by the use of the two best 4-electrodeconfiguration with regarding to the real volume obtained by pneumotachometer were of 15 ± 6%, 16 ± 4%and 43 ± 41%, respectively. The volume differences between the one obtained by the use of 16-electrodesand that for the best 4 electrode configuration were not significant. We conclude that although thedeterminations of impedance obtained by the best 4-electrode configuration has a lower sensitivity thanthose obtained by the 16-electrodes, it is possible to measure the respiratory pattern in healthy males