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dc.contributor.authorAguado-Sierra, Jazmin
dc.contributor.authorSantiago, Alfonso
dc.contributor.authorRivero, Matías I.
dc.contributor.authorLopez-Yunta, Mariña
dc.contributor.authorSoto-Iglesias, David
dc.contributor.authorDux-Santoy, Lydia
dc.contributor.authorCamara, Oscar
dc.contributor.authorVázquez, Mariano
dc.contributor.otherBarcelona Supercomputing Center
dc.date.accessioned2016-04-14T13:42:31Z
dc.date.available2016-04-14T13:42:31Z
dc.date.issued2015-01-01
dc.identifier.citationAguado-Sierra, Jazmin [et al.]. Fully-Coupled Electromechanical Simulations of the LV Dog Anatomy Using HPC: Model Testing and Verification. A: "Statistical Atlases and Computational Models of the Heart - Imaging and Modelling Challenges". Springer, 2015, p. 114-122.
dc.identifier.isbn978-3-319-14677-5
dc.identifier.urihttp://hdl.handle.net/2117/85690
dc.description.abstractVerification of electro-mechanic models of the heart require a good amount of reliable, high resolution, thorough in-vivo measurements. The detail of the mathematical models used to create simulations of the heart beat vary greatly. Generally, the objective of the simulation determines the modeling approach. However, it is important to exactly quantify the amount of error between the various approaches that can be used to simulate a heart beat by comparing them to ground truth data. The more detailed the model is, the more computing power it requires, we therefore employ a high-performance computing solver throughout this study. We aim to compare models to data measured experimentally to identify the effect of using a mathematical model of fibre orientation versus the measured fibre orientations using DT-MRI. We also use simultaneous endocardial stimuli vs an instantaneous myocardial stimulation to trigger the mechanic contraction. Our results show that synchronisation of the electrical and mechanical events in the heart beat are necessary to create a physiological timing of hemodynamic events. Synchronous activation of all of the myocardium provides an unrealistic timing of hemodynamic events in the cardiac cycle. Results also show the need of establishing a protocol to quantify the zero-pressure configuration of the left ventricular geometry to initiate the simulation protocol; however, the predicted zero-pressure configuration of the same geometry was different, depending on the origin of the fibre field employed.
dc.description.sponsorshipThis work has been done with the support of the grant SEV-2011-00067 of Severo Ochoa Program, awarded by the Spanish Government to the Barcelona Supercomputing Center. Part of the research leading to these results has received funding from the Seventh Framework Programme (FP7/2007-2013) under grant agreement n 611823. It has also been partially funded from the by the Spanish Ministry of Economy and Competitiveness (TIN2011-28067).
dc.format.extent8 p.
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesLecture Notes in Computer Science, 8896
dc.subjectÀrees temàtiques de la UPC::Enginyeria electrònica
dc.subject.lcshHigh performance computing
dc.subject.lcshHeart beat--Mathematical models
dc.subject.otherHigh-Performance Computing (HPC)
dc.subject.otherElectromechanical simulations
dc.subject.otherCanine model
dc.subject.otherGround-truth data
dc.subject.otherVerification
dc.titleFully-Coupled Electromechanical Simulations of the LV Dog Anatomy Using HPC: Model Testing and Verification
dc.typePart of book or chapter of book
dc.subject.lemacCardiologia--Investigació
dc.subject.lemacCàlcul intensiu (Informàtica)
dc.identifier.doi10.1007/978-3-319-14678-2_12
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://link.springer.com/chapter/10.1007%2F978-3-319-14678-2_12
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/SEV-2011-00067
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/611823/EU/Computer model derived indices for optimal patient-specific treatment selection and planning in Heart Failure/VP2HF
dc.relation.projectidinfo:eu-repo/grantAgreement/MINECO/6PN/TIN2011-28067
local.citation.publicationNameStatistical Atlases and Computational Models of the Heart - Imaging and Modelling Challenges
local.citation.startingPage114
local.citation.endingPage122


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