Show simple item record

dc.contributor.authorGodoy Gallardo, Maria
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorSevilla Sánchez, Pablo
dc.contributor.authorManero Planella, José María
dc.contributor.authorGil Mur, Francisco Javier
dc.contributor.authorRodríguez Rius, Daniel
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2016-04-11T11:30:18Z
dc.date.available2018-02-01T01:30:39Z
dc.date.issued2016-02-01
dc.identifier.citationGodoy, M., Guillem-Marti, J., Sevilla, P., Manero, J., Gil, F.J., Rodriguez, D. Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation. "Materials science and engineering C. Biomimetic and supramolecular systems", 01 Febrer 2016, vol. 59, p. 524-532.
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/2117/85475
dc.description.abstractBacterial infection in dental implants along with osseointegration failure usually leads to loss of the device. Bioactive molecules with antibacterial properties can be attached to titanium surfaces with anchoring molecules such as silanes, preventing biofilm formation and improving osseointegration. Properties of silanes as molecular binders have been thoroughly studied, but research on the biological effects of these coatings is scarce. The aim of the present study was to determine the in vitro cell response and antibacterial effects of triethoxysilypropyl succinic anhydride (TESPSA) silane anchored on titanium surfaces. X-ray photoelectron spectroscopy confirmed a successful silanization. The silanized surfaces showed no cytotoxic effects. Gene expression analyses of Sarcoma Osteogenic (SaOS-2) osteoblast-like cells cultured on TESPSA silanized surfaces reported a remarkable increase of biochemical markers related to induction of osteoblastic cell differentiation. A manifest decrease of bacterial adhesion and biofilm formation at early stages was observed on treated substrates, while favoring cell adhesion and spreading in bacteria-cell co-cultures.; Surfaces treated with TESPSA could enhance a biological sealing on implant surfaces against bacteria colonization of underlying tissues. Furthermore, it can be an effective anchoring platform of biomolecules on titanium surfaces with improved osteoblastic differentiation and antibacterial properties. (C) 2015 Elsevier B.V. All rights reserved.
dc.format.extent9 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshBiofilms
dc.subject.lcshBiomedical materials
dc.subject.lcshTitanium
dc.subject.otherBacterial adhesion
dc.subject.otherBiofilm
dc.subject.otherOsteoblast differentiation
dc.subject.otherSilane
dc.subject.otherTitanium
dc.subject.othertissue integration
dc.subject.othersilanization
dc.subject.otherbiomaterial
dc.subject.othergrowth
dc.subject.otherenergy
dc.subject.other3-aminopropyltriethoxysilane
dc.subject.otherattachment
dc.subject.otherexpression
dc.subject.otherroughness
dc.subject.otherpeptide
dc.titleAnhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation
dc.typeArticle
dc.subject.lemacBiofilms
dc.subject.lemacTitani -- Aplicacions mèdiques
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.msec.2015.10.051
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0928493115304823
dc.rights.accessOpen Access
drac.iddocument17546739
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706
upcommons.citation.authorGodoy, M., Guillem-Marti, J., Sevilla, P., Manero, J., Gil, F.J., Rodriguez, D.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameMaterials science and engineering C. Biomimetic and supramolecular systems
upcommons.citation.volume59
upcommons.citation.startingPage524
upcommons.citation.endingPage532


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain