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dc.contributor.authorAlonso López, Joan Francesc
dc.contributor.authorRomero Lafuente, Sergio
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorRojas Martínez, Mónica
dc.contributor.authorRiba Serrano, Jordi
dc.contributor.authorBarbanoj, Manuel José
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2016-04-05T10:51:53Z
dc.date.available2016-06-06T00:30:17Z
dc.date.issued2015-10-01
dc.identifier.citationAlonso, J.F., Romero, S., Mañanas, M.A., Rojas, M., Riba, J., Barbanoj, M.J. Evaluation of multiple comparison correction procedures in drug assessment studies using LORETA maps. "Medical and biological engineering and computing", 01 Octubre 2015, vol. 53, núm. 10, p. 1011-1023.
dc.identifier.issn0140-0118
dc.identifier.urihttp://hdl.handle.net/2117/85186
dc.description.abstractThe identification of the brain regions involved in the neuropharmacological action is a potential procedure for drug development. These regions are commonly determined by the voxels showing significant statistical differences after comparing placebo-induced effects with drug-elicited effects. LORETA is an electroencephalography (EEG) source imaging technique frequently used to identify brain structures affected by the drug. The aim of the present study was to evaluate different methods for the correction of multiple comparisons in the LORETA maps. These methods which have been commonly used in neuroimaging and also simulated studies have been applied on a real case of pharmaco-EEG study where the effects of increasing benzodiazepine doses on the central nervous system measured by LORETA were investigated. Data consisted of EEG recordings obtained from nine volunteers who received single oral doses of alprazolam 0.25, 0.5, and 1 mg, and placebo in a randomized crossover double-blind design. The identification of active regions was highly dependent on the selected multiple test correction procedure. The combined criteria approach known as cluster mass was useful to reveal that increasing drug doses led to higher intensity and spread of the pharmacologically induced changes in intracerebral current density.
dc.format.extent13 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
dc.subject.lcshBrain mapping
dc.subject.lcshNeuropharmacology
dc.subject.otherEEG tomography
dc.subject.otherLORETA
dc.subject.otherMultiple testing
dc.subject.otherNonparametric permutation test
dc.subject.otherCluster mass
dc.subject.otherAlprazolam
dc.subject.otherRESOLUTION ELECTROMAGNETIC TOMOGRAPHY
dc.subject.otherBRAIN ELECTRICAL-ACTIVITY
dc.subject.otherFALSE DISCOVERY RATE
dc.subject.otherDOUBLE-BLIND
dc.subject.otherALZHEIMERS-DISEASE
dc.subject.otherPHARMACODYNAMICS
dc.subject.otherPERMUTATION
dc.subject.otherBUSPIRONE
dc.subject.otherTESTS
dc.subject.otherVOXEL
dc.titleEvaluation of multiple comparison correction procedures in drug assessment studies using LORETA maps
dc.typeArticle
dc.subject.lemacCartografia cerebral
dc.subject.lemacNeurofarmacologia
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy
dc.identifier.doi10.1007/s11517-015-1315-6
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs11517-015-1315-6
dc.rights.accessOpen Access
local.identifier.drac15887234
dc.description.versionPostprint (author's final draft)
local.citation.authorAlonso, J.F.; Romero, S.; Mañanas, M.A.; Rojas, M.; Riba, J.; Barbanoj, M.J.
local.citation.publicationNameMedical and biological engineering and computing
local.citation.volume53
local.citation.number10
local.citation.startingPage1011
local.citation.endingPage1023


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