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dc.contributor.authorVazquez Fresno, Rosa
dc.contributor.authorLlorach Asunción, Rafael
dc.contributor.authorPerera Lluna, Alexandre
dc.contributor.authorMandal, Rupasri
dc.contributor.authorFeliz, Miguel
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorWishart, David
dc.contributor.authorAndres Lacueva, Cristina
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2016-03-31T15:17:24Z
dc.date.available2017-05-16T00:30:30Z
dc.date.issued2016-02-01
dc.identifier.citationVazquez, R., Llorach, R., Perera, A., Mandal, R., Feliz, M., Tinahones, F., Wishart, D., Andres, C. Clinical phenotype clustering in cardiovascular risk patients for the identification of responsive metabotypes after red wine polyphenol intake. "Journal of nutritional biochemistry", 01 Febrer 2016, vol. 28, p. 114-120.
dc.identifier.issn0955-2863
dc.identifier.urihttp://hdl.handle.net/2117/85014
dc.description.abstract© 2015 Elsevier Inc. This study aims to evaluate the robustness of clinical and metabolic phenotyping through, for the first time, the identification of differential responsiveness to dietary strategies in the improvement of cardiometabolic risk conditions. Clinical phenotyping of 57 volunteers with cardiovascular risk factors was achieved using k-means cluster analysis based on 69 biochemical and anthropometric parameters. Cluster validation based on Dunn and Figure of Merit analysis for internal coherence and external homogeneity were employed. k-Means produced four clusters with particular clinical profiles. Differences on urine metabolomic profiles among clinical phenotypes were explored and validated by multivariate orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) models. OSC-PLS-DA of 1H-NMR data revealed that model comparing
dc.format.extent7 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Aparells mèdics::Aparells cardiovasculars
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia
dc.subject.other4-Hydroxyphenylacetate
dc.subject.otherCardiovascular disease
dc.subject.otherGut microbiota
dc.subject.otherMetabolic phenotype
dc.subject.otherMetabolomics
dc.subject.otherMetabotype
dc.subject.otherNMR
dc.subject.otherWine polyphenols
dc.titleClinical phenotype clustering in cardiovascular risk patients for the identification of responsive metabotypes after red wine polyphenol intake
dc.typeArticle
dc.subject.lemacBiotecnologia
dc.contributor.groupUniversitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics
dc.identifier.doi10.1016/j.jnutbio.2015.10.002
dc.rights.accessOpen Access
local.identifier.drac17677232
dc.description.versionPostprint (published version)
local.citation.authorVazquez, R.; Llorach, R.; Perera, A.; Mandal, R.; Feliz, M.; Tinahones, F.; Wishart, D.; Andres, C.
local.citation.publicationNameJournal of nutritional biochemistry
local.citation.volume28
local.citation.startingPage114
local.citation.endingPage120


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