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dc.contributor.authorCatuara, Silvina
dc.contributor.authorEspinosa Carrasco, Jose
dc.contributor.authorErb, Ionas
dc.contributor.authorLangohr, Klaus
dc.contributor.authorNotredame, Cedric
dc.contributor.authorGonzalez, Juan R.
dc.contributor.authorDierssen, Mara
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2016-03-30T11:28:05Z
dc.date.available2016-03-30T11:28:05Z
dc.date.issued2015-12-11
dc.identifier.citationCatuara, S., Espinosa, J., Erb, I., Langohr, K., Notredame, C., Gonzalez, J., Dierssen, M. Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of Down Syndrome. "Frontiers in Behavioral Neuroscience", 11 Desembre 2015, vol. 9, p. 1-14.
dc.identifier.issn1662-5153
dc.identifier.urihttp://hdl.handle.net/2117/84867
dc.description.abstractDown syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn mice, a segmental trisomy model of DS that partially mimics DS/AD pathology, at the age of initiation of cognitive decline. Classical repeated measures ANOVA showed that combined EE-EGCG treatment was more efficient than FE or EGCG alone to improve specific spatial learning related variables. Using principal component analysis (PCA) we found that several spatial learning parameters contributed similarly to a first PC and explained a large proportion of the variance among groups, thus representing a composite learning measure. This PC1 revealed that EGCG or FE alone had no significant effect. However, combined FE-EGCG significantly ameliorated learning alterations of middle age Ts65Dn mice. Interestingly. PCA revealed an increased variability along learning sessions with good and poor learners in Ts65Dn, and this stratification did not disappear upon treatments. Our results suggest that combining EE and EGCG represents a viable therapeutic approach for amelioration of age-related cognitive decline in DS, although its efficacy may vary across individuals.
dc.format.extent14 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa::Simulació
dc.subject.lcshOperations research
dc.subject.otherDown syndrome
dc.subject.otheraging
dc.subject.other(-)-epigallocatechin-3-gallate
dc.subject.otherMorris water maze
dc.subject.otherprincipal component analysis
dc.subject.otherMORRIS WATER MAZE
dc.subject.otherGREEN TEA POLYPHENOL
dc.subject.otherALZHEIMERS-DISEASE
dc.subject.otherCOGNITIVE DEFICITS
dc.subject.otherTRANSGENIC MICE
dc.subject.otherTS65DN MICE
dc.subject.otherNEUROPATHOLOGICAL CHANGES
dc.subject.otherCEREBRAL-CORTEX
dc.subject.otherBRAIN
dc.subject.otherPROTEIN
dc.titlePrincipal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of Down Syndrome
dc.typeArticle
dc.subject.lemacInvestigació operativa
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.identifier.doi10.3389/fnbeh.2015.00330
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::90 Operations research, mathematical programming::90B Operations research and management science
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fnbeh.2015.00330/full
dc.rights.accessOpen Access
local.identifier.drac17511502
dc.description.versionPostprint (published version)
local.citation.authorCatuara, S.; Espinosa, J.; Erb, I.; Langohr, K.; Notredame, C.; Gonzalez, J.; Dierssen, M.
local.citation.publicationNameFrontiers in Behavioral Neuroscience
local.citation.volume9
local.citation.startingPage1
local.citation.endingPage14
dc.identifier.pmid26696850


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