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Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of Down Syndrome

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10.3389/fnbeh.2015.00330
 
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Catuara, Silvina
Espinosa Carrasco, Jose
Erb, Ionas
Langohr, KlausMés informacióMés informacióMés informació
Notredame, Cedric
Gonzalez, Juan R.
Dierssen, Mara
Document typeArticle
Defense date2015-12-11
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Down syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn mice, a segmental trisomy model of DS that partially mimics DS/AD pathology, at the age of initiation of cognitive decline. Classical repeated measures ANOVA showed that combined EE-EGCG treatment was more efficient than FE or EGCG alone to improve specific spatial learning related variables. Using principal component analysis (PCA) we found that several spatial learning parameters contributed similarly to a first PC and explained a large proportion of the variance among groups, thus representing a composite learning measure. This PC1 revealed that EGCG or FE alone had no significant effect. However, combined FE-EGCG significantly ameliorated learning alterations of middle age Ts65Dn mice. Interestingly. PCA revealed an increased variability along learning sessions with good and poor learners in Ts65Dn, and this stratification did not disappear upon treatments. Our results suggest that combining EE and EGCG represents a viable therapeutic approach for amelioration of age-related cognitive decline in DS, although its efficacy may vary across individuals.
CitationCatuara, S., Espinosa, J., Erb, I., Langohr, K., Notredame, C., Gonzalez, J., Dierssen, M. Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of Down Syndrome. "Frontiers in Behavioral Neuroscience", 11 Desembre 2015, vol. 9, p. 1-14. 
URIhttp://hdl.handle.net/2117/84867
DOI10.3389/fnbeh.2015.00330
ISSN1662-5153
Publisher versionhttp://journal.frontiersin.org/article/10.3389/fnbeh.2015.00330/full
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