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dc.contributor.authorBachiller Matarranz, Alejandro
dc.contributor.authorRomero Lafuente, Sergio
dc.contributor.authorMolina, Vicente
dc.contributor.authorAlonso López, Joan Francesc
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorPoza Crespo, Jesús
dc.contributor.authorHornero Sánchez, Roberto
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.identifier.citationBachiller, A., Romero, S., Molina, V., Alonso, J.F., Mañanas, M.A., Poza, J., Hornero, R. Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach. "Schizophrenia research", Desembre 2015, vol. 169, p. 318-325.
dc.description.abstractThe present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by time-averaging of low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects’ P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes, whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in a cognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitive processes and underlying mechanisms in Sz.
dc.format.extent8 p.
dc.subjectÀrees temàtiques de la UPC::Enginyeria electrònica::Instrumentació i mesura
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.othersource localization
dc.subject.otherevent-related potentials
dc.subject.otherwindow of interest
dc.subject.otherP3a and P3b
dc.titleAuditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach
dc.subject.lemacEnginyeria biomèdica
dc.subject.lemacMonitoratge de pacients
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
local.citation.authorBachiller, A.; Romero, S.; Molina, V.; Alonso, J.F.; Mañanas, M.A.; Poza, J.; Hornero, R.
local.citation.publicationNameSchizophrenia research

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