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Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

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10.1016/j.schres.2015.09.028
 
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Bachiller Matarranz, AlejandroMés informacióMés informacióMés informació
Romero Lafuente, SergioMés informacióMés informacióMés informació
Molina, Vicente
Alonso López, Joan FrancescMés informacióMés informacióMés informació
Mañanas Villanueva, Miguel ÁngelMés informacióMés informacióMés informació
Poza Crespo, Jesús
Hornero Sánchez, Roberto
Document typeArticle
Defense date2015-12
Rights accessOpen Access
All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder
Abstract
The present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by time-averaging of low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects’ P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes, whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in a cognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitive processes and underlying mechanisms in Sz.
CitationBachiller, A., Romero, S., Molina, V., Alonso, J.F., Mañanas, M.A., Poza, J., Hornero, R. Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach. "Schizophrenia research", Desembre 2015, vol. 169, p. 318-325. 
URIhttp://hdl.handle.net/2117/84740
DOI10.1016/j.schres.2015.09.028
ISSN0920-9964
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  • Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial - Articles de revista [1.538]
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