Comment on ‘protein–protein binding affinity prediction from amino acid sequence
Rights accessOpen Access
All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder
ProjectEEPPIBM - Exploring the evolution of protein-protein interactions and their networks using biophysical models (EC-FP7-327899)
Predicting the strength of interactions between globular proteins is a central and important topic in structural bioinformatics (Moal et al., 2013). The amino acid sequence represents the chemical bonding in a protein which, along with the solvent, dictates how it folds into an ensemble of thermally accessible states. In turn, structure specifies the strength and identity of its binding partners, by establishing the specific arrangements of intermolecular interactions and the intramolecular strain required to achieve them.
CitationMoal, Iain H.; Fernández-Recio, Juan. Comment on ‘protein–protein binding affinity prediction from amino acid sequence. "Bioinformatics", 17 Octubre 2014, vol. 31, núm. 4, p. 614-615.