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Optogenetics comes of age: novel inhibitory light-gated anionic channels allow efficient silencing of neural function
dc.contributor.author | Peralvarez Marin, Alex |
dc.contributor.author | Garriga Solé, Pere |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2016-03-16T14:53:06Z |
dc.date.available | 2017-01-05T01:30:26Z |
dc.date.issued | 2016-02-02 |
dc.identifier.citation | Peralvarez, A., Garriga, P. Optogenetics comes of age: novel inhibitory light-gated anionic channels allow efficient silencing of neural function. "Chembiochem", 02 Febrer 2016, vol. 17, núm. 3, p. 204-206. |
dc.identifier.issn | 1439-4227 |
dc.identifier.uri | http://hdl.handle.net/2117/84512 |
dc.description | This is the peer reviewed version of the following article: A. Peralvárez-Marín, P. Garriga, Optogenetics Comes of Age: Novel Inhibitory Light-Gated Anionic Channels Allow Efficient Silencing of Neural Function. ChemBioChem 2016, 17, 204-206, which has been published in final form at http://dx.doi.org/10.1002/cbic.201500608. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving |
dc.description.abstract | Optogenetics, the developing field of research that uses light-switchable biochemical tools in a sophisticated technological approach to monitor or control neural function, is rapidly evolving with the discovery and development of novel microbial rhodopsins. Light-absorbing membrane proteins, as tools for brain research, are promoting new applications within the discipline of optogenetics. Light-gated rhodopsin ion channels with better intrinsic light sensitivity and improved resolution are needed to overcome some of the current limitations of existing molecules. The recent discovery of light-gated inhibitory anion channels opens new opportunities for studying physiological neural processes and, at the same time, represent a powerful approach for elucidating the mechanisms of neurological and mental disorders that could benefit from this approach. |
dc.format.extent | 3 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química::Química orgànica::Bioquímica |
dc.subject.lcsh | Neurobiology |
dc.subject.lcsh | Cellular signal transduction |
dc.subject.other | Brain function |
dc.subject.other | Light-activated ion channels |
dc.subject.other | Rhodopsins |
dc.subject.other | Signal transduction |
dc.title | Optogenetics comes of age: novel inhibitory light-gated anionic channels allow efficient silencing of neural function |
dc.type | Article |
dc.subject.lemac | Neurobiologia |
dc.subject.lemac | Transducció de senyal cel·lular |
dc.contributor.group | Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial |
dc.identifier.doi | 10.1002/cbic.201500608 |
dc.description.peerreviewed | Peer Reviewed |
dc.rights.access | Open Access |
local.identifier.drac | 17659553 |
dc.description.version | Postprint (published version) |
local.citation.author | Peralvarez, A.; Garriga, P. |
local.citation.publicationName | Chembiochem |
local.citation.volume | 17 |
local.citation.number | 3 |
local.citation.startingPage | 204 |
local.citation.endingPage | 206 |
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