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dc.contributor.authorZhao, Zhitong
dc.contributor.authorEspañol Pons, Montserrat
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorKempf, Doreen
dc.contributor.authorDíez Escudero, Anna
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2016-02-25T12:45:42Z
dc.date.available2016-02-25T12:45:42Z
dc.date.issued2016
dc.identifier.citationZhao, Z., Español, M., Guillem-Marti, J., Kempf, D., Diez, A., Ginebra, M.P. Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization. "Nanoscale", 2016, vol. 8, núm. 3, p. 1595-1607.
dc.identifier.issn2040-3364
dc.identifier.urihttp://hdl.handle.net/2117/83440
dc.description.abstractAlthough it is widely acknowledged that ionic substitutions on bulk hydroxyapatite substrates have a strong impact on their biological performance, little is known of their effect on nanoparticles (NPs) especially when used for gene transfection or drug delivery. The fact that NPs would be internalized poses many questions but also opens up many new possibilities. The objective of the present work is to synthesize and assess the effect of a series of hydroxyapatite-like (HA) NPs doped with various ions on cell behavior, i.e. carbonate, magnesium and co-addition. We synthesized NPs under similar conditions to allow comparison of results and different aspects in addition to assessing the effect of the doping ion(s) were investigated: (1) the effect of performing the cell culture study on citrate-dispersed NPs and on agglomerated NPs, (2) the effect of adding/excluding 10% of foetal bovine serum (FBS) in the cell culture media and (3) the type of cell, i.e. MG-63 versus rat mesenchymal stem cells (rMSCs). The results clearly demonstrated that Mg-doping had a major effect on MG-63 cells with high cytotoxicity but not to rMSCs. This was a very important finding because it proved that doping could be a tool to modify NP internalization. The results also suggest that NP surface charge had a large impact on MG-63 cells and prevents their internalization if it is too negative—this effect was less critical for rMSCs
dc.format.extent13 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshHydroxyapatite
dc.subject.lcshNanoparticles
dc.titleIon-doping as a strategy to modulate hydroxyapatite nanoparticle internalization
dc.typeArticle
dc.subject.lemacHidroxiapatita
dc.subject.lemacNanopartícules
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1039/c5nr05262a
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://pubs.rsc.org/en/Content/ArticleLanding/2016/NR/C5NR05262A#!divAbstract
dc.rights.accessOpen Access
local.identifier.drac17530038
dc.description.versionPostprint (author's final draft)
local.citation.authorZhao, Z.; Español, M.; Guillem-Marti, J.; Kempf, D.; Diez, A.; Ginebra, M.P.
local.citation.publicationNameNanoscale
local.citation.volume8
local.citation.number3
local.citation.startingPage1595
local.citation.endingPage1607


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