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dc.contributor.authorAlonso Merino, Cristina
dc.contributor.authorMartí Gelabert, Meritxell
dc.contributor.authorBarba Albanell, Cristina
dc.contributor.authorLis Arias, Manuel José
dc.contributor.authorRubio Toledano, Laura
dc.contributor.authorCoderch Negra, Luisa
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2016-02-22T11:06:49Z
dc.date.available2018-03-01T01:30:21Z
dc.date.issued2016-01-26
dc.identifier.citationAlonso, C., Martí, M., Barba, C., Lis, M., Rubio, L., Coderch, L. Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid. "Journal of photochemistry and photobiology B. Biology", 26 Gener 2016, vol. 156, p. 50-55.
dc.identifier.issn1011-1344
dc.identifier.urihttp://hdl.handle.net/2117/83231
dc.description.abstractIn this work, the antioxidant gallic acid (GA) has been encapsulated in microspheres prepared with poly-e-caprolactone (PCL) and incorporated into polyamide (PA) obtaining the cosmeto-textile. The topical application of the cosmeto-textile provides a reservoir effect in the skin delivery of GA. The close contact of the cosmeto-textile, containing microsphere-encapsulated GA (ME-GA), with the skin and their corresponding occlusion, may be the main reasons that explain the crossing of active principle (GA) through the skin barrier, located in the stratum corneum, and its penetration into the different compartments of the skin, epidermis and dermis. An ex vivo assessment was performed to evaluate the antioxidant effect of the ME-GA on the stratum corneum (SC) using the thiobarbituric acid-reactive species (TBARS) test. The test is based on a non-invasive ex vivo methodology that evaluates lipid peroxides formed in the outermost layers of the SC from human volunteers after UV radiation to determine the effectiveness of an antioxidant. In this case, a ME-GA cosmeto-textile or ME-GA formulation were applied to the skin in vivo and lipid peroxidation (LPO) in the horny layer were determined after UV irradiation. This methodology may be used as a quality control tool to determine ex vivo the percentage of LPO inhibition on human SC for a variety of antioxidants that are topically applied, in this case GA. Results show that LPO formation was inhibited in human SC when GA was applied directly or embedded in the cosmeto-textile, demonstrating the effectiveness of both applications. The percentage of LPO inhibition obtained after both topical applications was approximately 10% for the cosmeto-textile and 41% for the direct application of microspheres containing GA. This methodology could be used to determine the effectiveness of topically applied antioxidants encapsulated in cosmeto-textiles on human SC
dc.format.extent6 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química::Indústries químiques::Química tèxtil
dc.subjectÀrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdics
dc.subject.lcshCosmetic delivery systems
dc.subject.lcshSkin absorption
dc.subject.lcshMicrospheres
dc.subject.lcshMicrospheres, microcapsules & liposomes
dc.subject.lcshGallic acid
dc.subject.otherGallic acid
dc.subject.otherMicrospheres
dc.subject.otherCosmeto-textiles
dc.subject.otherSkin absorption
dc.subject.otherLipoperoxidation
dc.titleSkin penetration and antioxidant effect of cosmeto-textiles with gallic acid
dc.typeArticle
dc.subject.lemacÀcid orgànic
dc.subject.lemacTeixits i tèxtils -- Innovacions tecnològiques
dc.subject.lemacAbsorció (Fisiologia)
dc.subject.lemacLípids -- Oxidació
dc.subject.lemacMicroestructura
dc.contributor.groupUniversitat Politècnica de Catalunya. POLQUITEX - Materials Polimérics i Química Téxtil
dc.identifier.doi10.1016/j.jphotobiol.2016.01.014
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1011134415301068
dc.rights.accessOpen Access
local.identifier.drac17506635
dc.description.versionPostprint (author's final draft)
local.citation.authorAlonso, C.; Martí, M.; Barba, C.; Lis, M.; Rubio, L.; Coderch, L.
local.citation.publicationNameJournal of photochemistry and photobiology B. Biology
local.citation.volume156
local.citation.startingPage50
local.citation.endingPage55


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