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Coiled-coil conformation of a pentamidine-DNA complex
dc.contributor.author | Moreno Chicano, Tadeo |
dc.contributor.author | Pous, Joan |
dc.contributor.author | Subirana Torrent, Juan A. |
dc.contributor.author | Campos López, Josefina de Lourdes |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2010-07-21T10:17:45Z |
dc.date.available | 2010-07-21T10:17:45Z |
dc.date.created | 2010-03 |
dc.date.issued | 2010-03 |
dc.identifier.citation | Moreno, T. [et al.]. Coiled-coil conformation of a pentamidine-DNA complex. "Acta crystallographica. Section D, biological crystallography", Març 2010, vol. 66, p. 251-257. |
dc.identifier.issn | 0907-4449 |
dc.identifier.uri | http://hdl.handle.net/2117/8298 |
dc.description.abstract | The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A·T base pairs. |
dc.format.extent | 7 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.title | Coiled-coil conformation of a pentamidine-DNA complex |
dc.type | Article |
dc.subject.lemac | ADN -- Estructura |
dc.subject.lemac | Genètica molecular |
dc.contributor.group | Universitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques |
dc.identifier.doi | 10.1107/S0907444909055693 |
dc.relation.publisherversion | http://www.ncbi.nlm.nih.gov/pubmed/20179336 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 2188704 |
dc.description.version | Postprint (published version) |
local.citation.author | Moreno, T.; Pous, J.; Subirana, J.; Campos, J. |
local.citation.publicationName | Acta crystallographica. Section D, biological crystallography |
local.citation.volume | 66 |
local.citation.startingPage | 251 |
local.citation.endingPage | 257 |
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