Mostra el registre d'ítem simple

dc.contributor.authorMoreno Chicano, Tadeo
dc.contributor.authorPous, Joan
dc.contributor.authorSubirana Torrent, Juan A.
dc.contributor.authorCampos López, Josefina de Lourdes
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2010-07-21T10:17:45Z
dc.date.available2010-07-21T10:17:45Z
dc.date.created2010-03
dc.date.issued2010-03
dc.identifier.citationMoreno, T. [et al.]. Coiled-coil conformation of a pentamidine-DNA complex. "Acta crystallographica. Section D, biological crystallography", Març 2010, vol. 66, p. 251-257.
dc.identifier.issn0907-4449
dc.identifier.urihttp://hdl.handle.net/2117/8298
dc.description.abstractThe coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A·T base pairs.
dc.format.extent7 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.titleCoiled-coil conformation of a pentamidine-DNA complex
dc.typeArticle
dc.subject.lemacADN -- Estructura
dc.subject.lemacGenètica molecular
dc.contributor.groupUniversitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
dc.identifier.doi10.1107/S0907444909055693
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pubmed/20179336
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac2188704
dc.description.versionPostprint (published version)
local.citation.authorMoreno, T.; Pous, J.; Subirana, J.; Campos, J.
local.citation.publicationNameActa crystallographica. Section D, biological crystallography
local.citation.volume66
local.citation.startingPage251
local.citation.endingPage257


Fitxers d'aquest items

Imatge en miniatura

Aquest ítem apareix a les col·leccions següents

Mostra el registre d'ítem simple