Coiled-coil conformation of a pentamidine-DNA complex
View/Open
coiled.pdf (818,1Kb) (Restricted access)
Request copy
Què és aquest botó?
Aquest botó permet demanar una còpia d'un document restringit a l'autor. Es mostra quan:
- Disposem del correu electrònic de l'autor
- El document té una mida inferior a 20 Mb
- Es tracta d'un document d'accés restringit per decisió de l'autor o d'un document d'accés restringit per política de l'editorial
Document typeArticle
Defense date2010-03
Rights accessRestricted access - publisher's policy
Abstract
The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A·T base pairs.
CitationMoreno, T. [et al.]. Coiled-coil conformation of a pentamidine-DNA complex. "Acta crystallographica. Section D, biological crystallography", Març 2010, vol. 66, p. 251-257.
ISSN0907-4449
Publisher versionhttp://www.ncbi.nlm.nih.gov/pubmed/20179336
Files | Description | Size | Format | View |
---|---|---|---|---|
coiled.pdf![]() | 818,1Kb | Restricted access |
Except where otherwise noted, content on this work
is licensed under a Creative Commons license
:
Attribution-NonCommercial-NoDerivs 3.0 Spain