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dc.contributor.authordel Hoyo, Laura
dc.contributor.authorXicota, Laura
dc.contributor.authorSánchez Benavides, Gonzalo
dc.contributor.authorCuenca Royo, Aida
dc.contributor.authorde Sola Llopis, Susana
dc.contributor.authorLangohr, Klaus
dc.contributor.authorFagundo, Ana Beatriz
dc.contributor.authorFarré, Magí
dc.contributor.authorDierssen, Mara
dc.contributor.authorDe la Torre Fornell, Rafael
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2016-02-15T12:33:01Z
dc.date.available2016-02-15T12:33:01Z
dc.date.issued2015-11-18
dc.identifier.citationdel Hoyo, L., Xicota, L., Sánchez Benavides, G., Cuenca, A., de Sola, S., Langohr, K., Fagundo, A., Farré, M., Dierssen, M., De la Torre, R. Semantic verbal fluency pattern, dementia rating scores and adaptive behavior correlate with plasma Aß42 concentrations in down syndrome young adults. "Frontiers in Behavioral Neuroscience", 18 Novembre 2015, vol. 9, núm. 301, p. 1-9.
dc.identifier.issn1662-5153
dc.identifier.urihttp://hdl.handle.net/2117/82928
dc.description.abstract© 2015 Del Hoyo, Xicota, Sánchez-Benavides, Cuenca-Royo, de Sola, Langohr, Fagundo, Farre, Dierssen and de La Torre. Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer’s disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of Aß peptides (Aß40 and Aß42), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma Aß42 concentrations, a higher DMR score and impaired communication skills (ABAS–II). The total word production and switching ability in SVFT were good indicators of plasma Aß42 concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS.
dc.format.extent9 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subject.lcshBiomathematics
dc.subject.otherAlzheimer’s disease
dc.subject.otherAmyloid precursor protein
dc.subject.other
dc.subject.otherCommunication skills
dc.subject.otherDMR
dc.subject.otherDown syndrome
dc.subject.otherSemantic verbal fluency
dc.subject.otherSwitching
dc.titleSemantic verbal fluency pattern, dementia rating scores and adaptive behavior correlate with plasma Aß42 concentrations in down syndrome young adults
dc.typeArticle
dc.subject.lemacBiologia -- Models matemàtics
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.identifier.doi10.3389/fnbeh.2015.00301
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
dc.rights.accessOpen Access
local.identifier.drac17429520
dc.description.versionPostprint (author's final draft)
local.citation.authordel Hoyo, L.; Xicota, L.; Sánchez Benavides, G.; Cuenca, A.; de Sola, S.; Langohr, K.; Fagundo, A.; Farré, M.; Dierssen, M.; De la Torre, R.
local.citation.publicationNameFrontiers in Behavioral Neuroscience
local.citation.volume9
local.citation.number301
local.citation.startingPage1
local.citation.endingPage9
dc.identifier.pmid26635555


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