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A shared-parameter joint model for prostate cancer risk and psa longitudinal profiles

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Serrat Piè, CarlesMés informacióMés informacióMés informació
Rué, Montserrat
Perpiñán Fabuel, Hèctor
Forte, Anabel
Armero, Carmen
Piulachs Lozada Benavente, XavierMés informacióMés informacióMés informació
Páez, Álvaro
Gómez Melis, GuadalupeMés informacióMés informacióMés informació
Document typeConference report
Defense date2015
PublisherFundación Mapfre
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds to the screening arm of the Spanish branch of the European Randomized Screening for Prostate Cancer (ERSPC) study. The results show that PSA is highly associated with the risk of being diagnosed with PCa and that there is an age-varying effect of PSA on PCa risk. Both the frequentist and Bayesian paradigms produced very close parameter estimates and subsequent 95% confidence and credibility intervals. Dynamic estimations of disease-free probabilities obtained using Bayesian inference highlight the potential of joint models to guide personalized risk-based screening strategies.
CitationSerrat, C., Rué, M., Perpiñán, H., Forte, A., Armero, C., Piulachs, X., Páez, Á., Gomez, G. A shared-parameter joint model for prostate cancer risk and psa longitudinal profiles. A: International Conference on Risk Analysis. "Current topics on risk analysis: ICRA 6 and RISK 2015 conference". Barcelona: Fundación Mapfre, 2015, p. 711-719. 
URIhttp://hdl.handle.net/2117/82670
DLM-17626-2015
ISBN978-84-9844-496-4
Publisher versionhttp://www.mapfre.com/documentacion/publico/i18n/catalogo_imagenes/grupo.cmd?path=1083273
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  • Departament de Matemàtiques - Ponències/Comunicacions de congressos [1.138]
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  • GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica - Ponències/Comunicacions de congressos [39]
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