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Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture
dc.contributor.author | Sachot, Nadège |
dc.contributor.author | Mateos Timoneda, Miguel Ángel |
dc.contributor.author | Planell Estany, Josep Anton |
dc.contributor.author | Velders, A. H. |
dc.contributor.author | lewandowska, M. |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.author | Castaño Linares, Óscar |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2016-01-29T12:20:02Z |
dc.date.available | 2016-01-29T12:20:02Z |
dc.date.issued | 2015-01-01 |
dc.identifier.citation | Sachot, N., Mateos, M., Planell, J., Velders, A., lewandowska, M., Engel, E., Castaño, O. Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture. "Nanoscale", 01 Gener 2015, vol. 7, núm. 37, p. 15349-15361. |
dc.identifier.issn | 2040-3364 |
dc.identifier.uri | http://hdl.handle.net/2117/82272 |
dc.description.abstract | Hybrid materials are being extensively investigated with the aim of mimicking the ECM microenvironment to develop effective solutions for bone tissue engineering. However, the common drawbacks of a hybrid material are the lack of interactions between the scaffold's constituents and the masking of its bioactive phase. Conventional hybrids often degrade in a non-homogeneous manner and the biological response is far from optimal. We have developed a novel material with strong interactions between constituents. The bioactive phase is directly exposed on its surface mimicking the structure of the ECM of bone. Here, polylactic acid electrospun fibers have been successfully and reproducibly coated with a bioactive organically modified glass (ormoglass, Si-Ca-P-2 system) covalently. In comparison with the pure polymeric mats, the fibers obtained showed improved hydrophilicity and mechanical properties, bioactive ion release, exhibited a nanoroughness and enabled good cell adhesion and spreading after just one day of culture (rMSCs and rEPCs). The fibers were coated with different ormoglass compositions to tailor their surface properties (roughness, stiffness, and morphology) by modifying the experimental parameters. Knowing that cells modulate their behavior according to the exposed physical and chemical signals, the development of this instructive material is a valuable advance in the design of functional regenerative biomaterials. |
dc.format.extent | 13 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Biomedical materials |
dc.subject.other | Bioactive glass |
dc.subject.other | mechanical-properties |
dc.subject.other | composite scaffolds |
dc.subject.other | bone regeneration |
dc.subject.other | extracellular calcium |
dc.subject.other | tissue regeneration |
dc.subject.other | in-vitro |
dc.subject.other | nanocomposites |
dc.subject.other | angiogenesis |
dc.subject.other | fabrication |
dc.title | Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture |
dc.type | Article |
dc.subject.lemac | Materials biomèdics |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1039/c5nr04275e |
dc.relation.publisherversion | http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR04275E#!divAbstract |
dc.rights.access | Open Access |
local.identifier.drac | 16991982 |
dc.description.version | Postprint (published version) |
local.citation.author | Sachot, N.; Mateos, M.; Planell, J.; Velders, A.; lewandowska, M.; Engel, E.; Castaño, O. |
local.citation.publicationName | Nanoscale |
local.citation.volume | 7 |
local.citation.number | 37 |
local.citation.startingPage | 15349 |
local.citation.endingPage | 15361 |
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